Linggui Zhugan Decoction activates the SIRT1-AMPK-PGC1 α signaling pathway to improve mitochondrial and oxidative damage in rats with chronic heart failure caused by myocardial infarction

Conclusion: Linggui Zhugan Decoction can improve the cardiac function of heart failure rats by enhancing myocardial antioxidant capacity and protecting the mitochondrial function, the mechanism is related to activating SIRT1/AMPK/PGC-1α signaling pathway.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research