Androgen deprivation therapy may lead to cognitive impairment in prostate cancer patients

Cognitive impairment can occur in cancer patients who are treated with a variety of therapies, including radiation therapy, hormone therapy, and chemotherapy. After chemotherapy treatment it is commonly called "chemo brain." Signs of cognitive impairment include forgetfulness, inability to concentrate, problems recalling information, trouble multi-tasking and becoming slower at processing information. The number of people who experience cognitive problems following cancer therapy is broad, with an estimate range of 15 to 70 percent.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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We report on an incidental detection of a meningioma on [18F]-2′-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) PET/CT scan that was performed during a prospective investigation of 18F-FMAU PET/CT for targeted biopsy of potential sites of tumor in men with suspected prostate cancer based on elevated prostate-specific antigen level. Neither prostate multiparamteric MRI nor 18F-FMAU PET/CT localized small volume Gleason 3 + 3 tumor deposits. However, an incidental focal high accumulation of 18F-FMAU was observed in high right parietal lobe that displayed characteristics of a meningioma on a subsequent brain MRI.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: Our study showed that for this single institution, scheduling is more difficult for 18F-Fluciclovine since their radiopharmacy is several hours away. This department can perform more studies per day with 18F-FDG. If another institution is closer to a radiopharmacy that provides 18F-Fluciclovine, they may be able to accommodate more patients per day. 18F-Fluciclovine patients can be scheduled every 40-45 minutes without the hour and a half uptake time.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: TS 22: Student Tech Papers II Source Type: research
Conclusions: We synthesized a novel PARP-1 radioligand, [18F]WC-DZ-F and demonstrated its potential in PET imaging of PARP-1 expression in the PC-3 model of PC by in vitro cell uptake studies, microPET imaging and postPET autoradiography, and biodistribution in normal mice. Further evaluation in other models of PC are warranted. Research Support: NIH: CA25836
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiolabeled Small Molecules and New Applications - Oncology Source Type: research
Conclusion: The overall results suggest clinical utility of Ga68-PSMA scan in prostate cancer. The Ga68-PSMA scan had high sensitivity with histopathological diagnosis. The scan was able to detect distant metastasis even with low Gleason scores. Ga68 PSMA is a valuable tool for prostate cancer staging .
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate Posters Source Type: research
Conclusion: Western blot studies confirmed high VPAC1 expression on the glioblastoma cell lines examined. 64Cu-TP3805 showed excellent labeling efficiency, and high uptake in glioblastoma. Targeting VPAC1 receptors using 64Cu-TP3805 for PET imaging of glioblastoma is a promising approach and calls for further investigation. Acknowledgements: The research, in part, was supported by NIH/NCI R01CA157372 (MLT), NIH/NCI 1S10OD012406 (MLT) and NIH/NCI S10RR23709 (MLT).
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research
Conclusions: L-1-[18F]FETrp highly accumulates in a wide range of malignancies including lung cancer, prostate cancer, and brain tumor. These PET imaging results suggested that L-1-[18F]FETrp is a promising radiotracer for cancer imaging. Research Support:This work was supported by the Simmons Cancer Center Grant (NIH 5P30 CA 142543), and American Cancer Society and the Simmons Cancer Center (ACS-IRG-02-196).Reference: Xin, Y. &Cai, H. Improved Radiosynthesis and Biological Evaluations of L- and D-1-[18F]Fluoroethyl-Tryptophan for PET Imaging of IDO-Mediated Kynurenine Pathway of Tryptophan Metabolism. Mol. Imaging Bio...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science Posters (Oncology) Source Type: research
Conclusions: PET imaging with radiolabeled amino acids has been shown be effective for brain tumor imaging, providing high contrast between tumor and normal brain parenchyma. The synthetic leucine amino acid analogue, fluciclovine has been recently FDA approved for evaluation of biochemical recurrent prostate cancer. Recent studies have been published demonstrating the utility of fluciclovine for glioma evaluation. Our findings suggest that fluciclovine can similarly be used for evaluation of new or recurrent brain metastasis in patients who previously have undergone brain radiotherapy where MRI is often limited due to bac...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology Posters Source Type: research
Conclusion The patient-based sensitivity, specificity and accuracy of WB MRI including DWI were comparable with those of PET/MRI. On the other hand, the lesion-based sensitivities of WB MRI were relatively low, mainly because of the low detectability of small lymph node metastasis. The combination of T2WI and DWI showed acceptable detectability; however, the T1WI sequence showed no additional value to detect malignant lesions on both lesion- and patient-based sensitivities.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors Posters Source Type: research
By SAURABH JHA Of my time arguing with doctors, 30 % is spent convincing British doctors that their American counterparts aren’t idiots, 30 % convincing American doctors that British doctors aren’t idiots, and 40 % convincing both that I’m not an idiot. A British doctor once earnestly asked whether American physicians carry credit card reading machines inside their white coats. Myths about the NHS can be equally comical. British doctors don’t prostate every morning in deference to the NHS, like the citizens of Oceania sang to Big Brother in Orwell’s dystopia. Nor, in their daily rounds, do the...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: OP-ED Uncategorized AlfieEvans Source Type: blogs
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