Androgen deprivation therapy may lead to cognitive impairment in prostate cancer patients

Cognitive impairment can occur in cancer patients who are treated with a variety of therapies, including radiation therapy, hormone therapy, and chemotherapy. After chemotherapy treatment it is commonly called "chemo brain." Signs of cognitive impairment include forgetfulness, inability to concentrate, problems recalling information, trouble multi-tasking and becoming slower at processing information. The number of people who experience cognitive problems following cancer therapy is broad, with an estimate range of 15 to 70 percent.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CONCLUSION: The study has made an attempt to provide evidence to the idea that GBX2 gene silencing has an inhibition effect on the proliferation, invasion and angiogenesis of the breast cancer cells by inhibiting the activation of the Wnt/β-catenin signaling pathway. PMID: 30223390 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers : Section A of Disease Markers - Category: Cancer & Oncology Authors: Tags: Cancer Biomark Source Type: research
Poly (ADP-ribose) polymerase-1 (PARP-1) plays many roles in prostate cancer (PC), such as mediating DNA damage repair, transcriptional regulation and nuclear hormone receptor signaling. Because of this, PARP-1 has been targeted for therapy in PC, and non-invasive imaging of PARP-1 could help predict which patients are likely to respond to such therapy. Several PARP-1 positron emission tomography (PET) imaging agents have been developed and show promise for imaging PARP-1 expression in breast, brain, and lung cancer in small animals, but not as yet in prostate cancer.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research
Genomics and Health Disparities Lecture Series John Carpten, PhD is Professor and Chair for the Department of Translational Genomics. His training and professional experiences include postdoctoral training at the National Human Genome Research Institute/NIH, and serving as Deputy Director of Research at the Translational Genomics Research Institute (TGen). Dr. Carpten ’ cancer research program spans multiple disciplines including germline genetics for disease risk and predisposition, somatic cancer genomics, health disparities research, cell biology, functional genomics, and precision medicine. The primary focus of h...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response. In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: STEM provides accurate simultaneous mapping of T1 , T2 , and ADC. This method may enable rapid and accurate multi-parametric tissue characterization for clinical and research applications. PMID: 30024051 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - Category: Radiology Authors: Tags: Magn Reson Med Source Type: research
Publication date: Available online 4 July 2018Source: Journal of Clinical NeuroscienceAuthor(s): Andrew Nunno, Mahlon D. Johnson, Guan Wu, Yan Michael LiAbstractOccurrences of metastatic prostate cancer imitating a subdural hematoma are limited to a small number of case reports, even though prostate cancer spreads to the dura more than other types of cancer. Here, we present the case of a 64 year-old male whose prostate carcinoma’s metastasis mimicked a subdural hematoma, and he suffered a middle cerebral artery stroke. Prostate cancer’s high rate of progression to the dura is disproportionate to its relative...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
We report on a patient with known stage IV adenocarcinoma of the prostate who presented with a recent onset of dizziness. Cranial magnetic resonance imaging demonstrated multiple cystic and nodular lesions throughout the brain parenchyma and cerebellum. At the time of diagnosis, the patient had normal PSA levels. The patient underwent palliative whole brain radiation and survived for 3 months after diagnosis with intracranial disease. We review the literature highlighting the incidence, treatment, and ongoing research endeavors to improve understanding of prostate cancer brain metastases.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
AbstractMalignancies of the central nervous system include primary brain tumors and brain metastases, the latter being the major cause of intracranial neoplasms in adults. Although prostate cancer (PCa) brain metastases are not the most common source, recent data show that the relevance of prostate cancer brain metastases (PCBM) cannot be neglected. In this review, we focus on the molecular repertory as well as on the phenotypical similarities between PCBM and primary PCa, such as the cellular evolution and the maintenance of androgen-receptor expression. Moreover, the simultaneous occurrence of PCBM with other PCa metasta...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 4 July 2018Source: Journal of Clinical NeuroscienceAuthor(s): Andrew Nunno, Mahlon D. Johnson, Guan Wu, Yan Michael LiAbstractOccurrences of metastatic prostate cancer imitating a subdural hematoma are limited to a small number of case reports, even though prostate cancer spreads to the dura more than other types of cancer. Here, we present the case of a 64 year-old male whose prostate carcinoma’s metastasis mimicked a subdural hematoma, and he suffered a middle cerebral artery stroke. Prostate cancer’s high rate of progression to the dura is disproportionate to its relative...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
We report on a patient with known stage IV adenocarcinoma of the prostate who presented with a recent onset of dizziness. Cranial magnetic resonance imaging demonstrated multiple cystic and nodular lesions throughout the brain parenchyma and cerebellum. At the time of diagnosis, the patient had normal PSA levels. The patient underwent palliative whole brain radiation and survived for 3 months after diagnosis with intracranial disease. We review the literature highlighting the incidence, treatment, and ongoing research endeavors to improve understanding of prostate cancer brain metastases.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
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