The diagnostic performance of functional dopaminergic scintigraphic imaging in the diagnosis of dementia with Lewy bodies: an updated systematic review

CONCLUSION: Our systematic review confirms the major role of dopaminergic scintigraphic imaging in the assessment of dementia with Lewy bodies. Early diagnosis could be facilitated by identifying the prodromes of dementia with Lewy bodies using dopaminergic scintigraphic imaging coupled with emphasis on clinical neuropsychiatric symptoms. Most published studies use a semi-quantitative analytical assessment of tracer uptake, while there are no studies using quantitative analytical methods to measure dopamine transporter loss. The superiority of a purely quantitative approach to assess dopaminergic transmission more accurately needs to be further clarified.PMID:36920494 | DOI:10.1007/s00259-023-06154-y

Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Mario Jreige George K Kurian J érémy Perriraz Jevita Potheegadoo Fosco Bernasconi Sara Stampacchia Olaf Blanke Griffa Alessandra Noemie Lejay Paolo Salvioni Chiabotti Olivier Rouaud Marie Nicod Lalonde Niklaus Schaefer Giorgio Treglia Gilles Allali John Source Type: research