Elevated IGF-1 induced female rats perpetuates the PCOS phenotype : Pathological mechanism of IGF-1 in polycystic ovary syndrome

Conclusions: These findings suggest that IGF-1 may be a key factor in the pathogenesis of PCOS, and the increase of androgen may be the pathological result, not the cause of polycystic ovary syndrome.
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research