USP48 alleviates bone cancer pain and regulates MrgC stabilization in spinal cord neurons of male mice

CONCLUSIONUSP48 antagonizes ubiquitin-mediated autophagic degradation of MrgC and alleviates bone cancer pain in a murine animal model. Our findings may provide a new perspective for the treatment of bone cancer pain.

Source: European Journal of Pain - March 3, 2023 Category: Anesthesiology Authors: Jiacheng Yu, Bailing Hou, Yulin Huang, Xiaoyu Wang, Yue Qian, Ying Liang, Xiaoping Gu, Zhengliang Ma, Yu ’e Sun Tags: ORIGINAL ARTICLE Source Type: research