Improving on the FOXN1-TAT Fusion Protein Approach for Thymic Regeneration

In this study, we develop a rFOXN1 fusion protein that contains the N-terminal of CCR9, FOXN1, and TAT. We show here that, when injected intravenously (i.v.) into aged mice, the rFOXN1 fusion protein can migrate into the thymus and enhance T cell generation in the thymus, resulting in increased number of peripheral T cells. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in the older adult. 

Source: Fight Aging! - March 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs