Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates

CONCLUSION: [11C]PyBic is the first brain-penetrant PARP PET tracer validated in a rat glioblastoma model and healthy nonhuman primates. The brain kinetics of [11C]PyBic are suitable for noninvasive quantification of available PARP binding in the brain, which posits [11C]PyBic to have broad applications in oncology and neuroimaging.PMID:36849748 | DOI:10.1007/s00259-023-06162-y

Source: Molecular Medicine - February 28, 2023 Category: Molecular Biology Authors: Baosheng Chen Devi Prasan Ojha Takuya Toyonaga Jie Tong Richard Pracitto Monique A Thomas Michael Liu Michael Kapinos Li Zhang Ming-Qiang Zheng Daniel Holden Krista Fowles Jim Ropchan Nabeel Nabulsi Henk De Feyter Richard E Carson Yiyun Huang Zhengxin Cai Source Type: research