A recurrent Pleomorphic Xanthoastrocytoma in the cerebellum in a young adult: A case report and review of the literature.

We present the 29th case in the literature and the first in Syria. Our p atient had a lesion in the right cerebellum and presented with a history of intermittent headache for 5 months followed by progressive gait disturbances and blurry vision and was misdiagnosed at the time of presentation with a high-grade glioma which is a common confusion because of the histological and clinical similarities. The patient underwent a suboccipital craniotomy and adjuvant therapy with a combination of radiotherapy and chemotherapy with Temozolomide (TMZ) was initiated at first. Then the patient presented with a relapse of symptoms and went through another surgery where frozen sec tions suggested the diagnosis of pleomorphic xanthoastrocytoma (PXA), further histopathological and immunohistochemical studies confirmed the diagnosis. Alongside highlighting the diagnostic challenge of this rare tumor, we did a brief review of the literature.
Source: Case Reports in Neurology - Category: Neurology Source Type: research