Impaired neurogenesis and neural progenitor fate choice in a human stem cell model of SETBP1 disorder

ConclusionsWe identified an important role for SETBP1 in controlling forebrain progenitor expansion and neurogenic differentiation. Our study establishes a novel regulatory link between SETBP1 and Wnt/β-catenin signaling during human cortical neurogenesis and provides mechanistic insights into structural abnormalities and potential therapeutic avenues for SETBP1 disorder.
Source: Molecular Autism - Category: Molecular Biology Source Type: research