Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosis

Emerging evidence suggests that crosstalk between Kupffer cells (KCs) and hepatocytes protects against non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms that lead to the reduction of steatosis in NAFLD remain obscure.

Source: Metabolism - Clinical and Experimental - February 9, 2023 Category: Biomedical Science Authors: Jeongmin Park, So-Young Rah, Hyeong Seok An, Jong Youl Lee, Gu Seob Roh, Stefan W. Ryter, Jeong Woo Park, Chae Ha Yang, Young-Joon Surh, Uh-Hyun Kim, Hun Taeg Chung, Yeonsoo Joe Source Type: research