Luseogliflozin and caloric intake restriction increase superoxide dismutase 2 expression, promote antioxidative effects, and attenuate aortic endothelial dysfunction in diet ‐induced obese mice

ConclusionsIt was shown that caloric restriction is important for the effect of luseogliflozin on metabolic parameters and endothelial dysfunction. Furthermore, SGLT2 inhibition by luseogliflozin possibly ameliorates FFA-induced endothelial dysfunction by increasing SOD2 expression and decreasing reactive oxygen species production in the thoracic aorta.

Source: Journal of Diabetes Investigation - February 2, 2023 Category: Endocrinology Authors: Shigeru Kawade, Kazuma Ogiso, Sigfrid Casmir Shayo, Takahiko Obo, Aiko Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Yoshihiko Nishio Tags: Original Article Source Type: research