Carotid dysfunction in senescent female mice is mediated by increased α < sub > 1A < /sub > -adrenoceptor activity and COX-derived vasoconstrictor prostanoids

In conclusion, senescence intensifies vasoconstriction mediated by a1A-adrenergic signaling in the carotid of female mice by mechanisms involving increased iCa+2 and release of cyclooxygenase-derived prostanoids.PMID:36705993 | DOI:10.1152/ajpheart.00495.2022

Source: American Journal of Physiology. Heart and Circulatory Physiology - January 27, 2023 Category: Physiology Authors: Tiago J Costa Paula R Barros Diego A Duarte J úlio A Silva-Neto Sara Cristina Hott Thamyris Santos-Silva Claudio M Costa-Neto Felipe V Gomes Eliana H Akamine Cameron G McCarthy Francesc Jim énez-Altayó Ana Paula Dantas Rita C Tostes Source Type: research