Role of G-Proteins and GPCRs in Cardiovascular Pathologies

Bioengineering (Basel). 2023 Jan 6;10(1):76. doi: 10.3390/bioengineering10010076.ABSTRACTCell signaling is a fundamental process that enables cells to survive under various ecological and environmental contexts and imparts tolerance towards stressful conditions. The basic machinery for cell signaling includes a receptor molecule that senses and receives the signal. The primary form of the signal might be a hormone, light, an antigen, an odorant, a neurotransmitter, etc. Similarly, heterotrimeric G-proteins principally provide communication from the plasma membrane G-protein-coupled receptors (GPCRs) to the inner compartments of the cells to control various biochemical activities. G-protein-coupled signaling regulates different physiological functions in the targeted cell types. This review article discusses G-proteins' signaling and regulation functions and their physiological relevance. In addition, we also elaborate on the role of G-proteins in several cardiovascular diseases, such as myocardial ischemia, hypertension, atherosclerosis, restenosis, stroke, and peripheral artery disease.PMID:36671648 | DOI:10.3390/bioengineering10010076
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research