The sodium iodide symporter (NIS) as theranostic gene: potential role in pre-clinical therapy of extra-thyroidal malignancies

ConclusionNIS-mediated expression in combination with  131I can be considered a promising  approach in the preclinical treatment of extra-thyroidal malignancies and metastases. Malignant cells expressing NIS are thought to accumulate radionuclides intracellularly, which contributes to the remarkable therapeutic effects observed.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research