Early-Stage Contactin-Associated Protein-like 2 Limbic Encephalitis: Clues for Diagnosis

Discussion
CASPR2-encephalitis has a progressive course and is highly heterogeneous at the early stage. In men older than 50 years, otherwise unexplained seizures, cerebellar ataxia, and/or neuropathic pain are suggestive of early-stage CASPR2-encephalitis, especially if they coincide with recent asthenia, mood disorders, or insomnia.

Source: Neurology Neuroimmunology and Neuroinflammation - October 26, 2022 Category: Neurology Authors: Benoit, J., Muniz-Castrillo, S., Vogrig, A., Farina, A., Pinto, A.-L., Picard, G., Rogemond, V., Guery, D., Alentorn, A., Psimaras, D., Rheims, S., Honnorat, J., Joubert, B. Tags: Research Article Source Type: research