Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy

Conclusion
Our study reveals a novel role for ANKRD1 as a selective regulator of PE-induced signalling whereby ANKRD1 recruits and localizes GATA4 and ERK1/2 in a sarcomeric macro-molecular complex to enhance GATA4 phosphorylation with subsequent nuclear translocation of the ANKRD1 complex to induce hypertrophic gene expression.

Source: Cardiovascular Research - April 16, 2015 Category: Cardiology Authors: Zhong, L., Chiusa, M., Cadar, A. G., Lin, A., Samaras, S., Davidson, J. M., Lim, C. C. Tags: Cardiac biology and remodelling Source Type: research