Impact of the WHO Integrated Stewardship Policy on the Control of Methicillin-Resistant Staphyloccus aureus and Third-Generation Cephalosporin-Resistant Escherichia coli: Using a Mathematical Modeling Approach

Methicillin-resistant Staphylococcus aureus (MRSA) and third-generation cephalosporin-resistant Escherichia coli (3GCREc) are community and hospital-associated pathogens causing serious infections among populations by infiltrating into hospitals and surrounding environment. These main multi-drug resistant or antimicrobial resistance (AMR) bacterial pathogens are threats to human health if not properly tackled and controlled. Tackling antimicrobial resistance (AMR) is one of the issues for the World Health Organization (WHO) to design a comprehensive set of interventions which also helps to achieve the end results of the developing indicators proposed by the same organization. A deterministic mathematical model is developed and studied to investigate the impact of the WHO policy on integrated antimicrobial stewardship activities to use effective protection measures to control the spread of AMR diseases such as MRSA and 3GCREc in hospital settings by incorporating the contribution of the healthcare workers in a hospital and the environment in the transmission dynamics of the diseases. The model also takes into account the parameters describing various intervention measures and is used to quantify their contribution in containing the diseases. The impact of combinations of various possible control measures on the overall dynamics of the disease under study is investigated. The model analysis suggests that the contribution of the interventions: screening and isolating the newly a...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news