CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer

CONCLUSIONS: Our findings support the application of CRISPR-Cas9 screening in identifying novel therapeutic targets and suggest new strategies for overcoming chemoresistance in pancreatic cancer.PMID:35945614 | DOI:10.1186/s13046-022-02443-w

Source: Cell Research - August 9, 2022 Category: Cytology Authors: Siyuan Zeng Bin Lan Xiaofan Ren Shuman Zhang Daniel Schreyer Markus Eckstein Hai Yang Nathalie Britzen-Laurent Andreas Dahl Debabrata Mukhopadhyay David Chang Isabella Kutschick Susanne Pfeffer Peter Bailey Andrew Biankin Robert Gr ützmann Christian Pila Source Type: research