A phase I dose escalation, dose expansion and pharmacokinetic trial of gemcitabine and alisertib in advanced solid tumors and pancreatic cancer

ConclusionsThis trial established the recommended phase 2 dose of alisertib 50  mg to be combined with gemcitabine. Gemcitabine and alisertib are a feasible strategy with potential for disease control in multiple heavily pre-treated tumors, though gastrointestinal and hematologic toxicity was apparent.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research