O-038 Sympathetic nervous system activation causes cerebral perfusion deficit and cerebral vasoconstriction in Swine

ConclusionIn swine, electrical stimulation of SCG results in reproducible cerebral vasoconstriction and perfusion deficit comparable to cerebral vasospasm. This can be inhibited by prior local anesthetic injection into the SCG, a possible therapeutic target for cerebral vasospasm.Abstract O-038 Figure 1CT perfusion scan (top row) coronel view of approximate fronto-temporal area of swine brain (outlined in white box) at baseline, with right SCG stimulation, with lidocainc + right SCG stimulation. Cerebral angiogram (bottom row) AP view of swine cranial artcrics at baseline, with right SCG stimulation, with lidocaine + right SCG stimulation. Small arrow: ACA. Arrowhead: aMCA. Large arrow: APADisclosures W. Kim: 1; C; NIH Research Education Programs (R25). M. Samarage: None. D. Zarrin: None. K. Goel: None. J. Johnson: None. A. Wang: None. G. Colby: 1; C; Casa Colina Foundation research grant.

Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kim, W., Samarage, M., Zarrin, D., Goel, K., Johnson, J., Wang, A., Colby, G. Tags: SNIS 19th annual meeting oral abstracts Source Type: research