Treatment with amoxicillin for 3 days for chest-indrawing pneumonia was non-inferior to treatment for 5 days in HIV-uninfected Malawian children

Review of: Perkin MR, Bahnson HT, Logan K, et al. Association of early introduction of solids with infant sleep. A secondary analysis of a randomized clinical trial. JAMA Pediatr 2018;172:e180739. Study design: This is a prospective, double-blinded, randomised, placebo controlled, non-inferiority trial. Allocation: Randomisation was used with 1:1 ratio according to age group and trial phase, in blocks of 2, 4 or 6. Study question Setting: The setting was two hospitals in a malaria-endemic area of Malawi. Patients: Patients studied were 3000 HIV-uninfected children, aged 2–59 months, who presented to the outpatient departments of the two sites and met the WHO criteria for the case definition of chest-indrawing pneumonia. Exclusion criteria included severe anaemia, severe respiratory distress at presentation, antibiotics in the previous 48 hours and presence of cough for more than 14 days. Intervention: Randomisation was used to either a 3-day regimen of high-dose amoxicillin or a 5-day...
Source: Archives of Disease in Childhood - Education and Practice - Category: Pediatrics Authors: Tags: Key publications in paediatrics: Picket Source Type: research