Insulin-Like Growth Factor-I Might be a Predictor for Severe Non-Alcoholic Fatty Liver Disease in Morbidly Obese Patients
This study was conducted on 316
morbidly obese patients (250 F/66 M). The data of
patients before and 1st-year after bariatric surgery were recorded. According to
the ultrasonographically NAFLD screening, patients with normal hepatic features
were classified as Group 1(n=57), with mild and moderate NAFLD were
classified as Group 2(n=219), and with severe NAFLD were classified as
Group 3(n=40). IGF-1 standard deviation scores (SDSIGF1) were calculated
according to age and gender. Parameters that could predict the presence and
severity of NAFLD were evaluated. IGF-1 levels were significantly associated
with Group 3 than Group 1(p=0.037), and the significance remained
between the same groups when IGF-1 levels were standardized as
SDSIGF1(p=0.036). Decreased levels of SDSIGF1 explained 5% of
severe NAFLD than the normal group (p=0.036). Liver Diameter, FPG, ALT,
AST, and GGT were also found as significant predictors for severe NAFLD. There
were significant differences between pre-and postop values in all groups
(p<0.001). This study showed that IGF-1 might be considered a sgnificant
predictor of severe NAFLD in morbidly obese patients. It is crucial in clinical
practice to determine predictive factors of NAFLD that could support the
diagnosis accompanied by non-invasive imaging methods. [...] Geo...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Turgut, Seda Acarer, Didem Seyit, Hakan Pamuk, Naim Piskinpasa, Hamide Bozkur, Evin Karabulut, Mehmet Cakir, Ilkay Tags: Original Article: Endocrine Care Source Type: research