Viruses, Vol. 14, Pages 1459: Fulminant Adenoviral-Induced Hepatitis in Immunosuppressed Patients

Viruses, Vol. 14, Pages 1459: Fulminant Adenoviral-Induced Hepatitis in Immunosuppressed Patients Viruses doi: 10.3390/v14071459 Authors: Juliane Kager Jochen Schneider Sebastian Rasch Peter Herhaus Mareike Verbeek Carolin Mogler Albert Heim Gert Frösner Dieter Hoffmann Roland M. Schmid Tobias Lahmer Human adenovirus (HAdV) can often lead to fulminant hepatitis in immunocompromised patients, mostly after reactivation of HAdV. Different risk factors, e.g., transplantation and chemotherapy, increase the risk of developing a HAdV hepatitis. We retrospectively analyzed three patients who showed the characteristics of a HAdV hepatitis observed in disseminated disease. In addition to PCR, diagnosis could be proven by pathology, CT scan, and markedly elevated transaminases. All patients had a hemato-oncologic underlying disease. Two had received a stem-cell transplant, and one was under chemotherapy including rituximab. Despite therapy with cidofovir, all patients died. As the incidence of HAdV hepatitis is low, diagnosis may be easily overlooked. No treatment approaches have yet been established. HAdV hepatitis should be considered as a differential diagnosis, especially when risk factors are present. To avoid dissemination, treatment should be initiated as soon as possible.
Source: Viruses - Category: Virology Authors: Tags: Case Report Source Type: research