Review of Suicidality Events in Perampanel Clinical Studies (S31.001)

CONCLUSIONS: The data reflect the clinical trial experience for suicidal ideation/behavior events. The perampanel USPI contains a class warning for suicidal behavior/ideation. Patients on AEDs, including perampanel, should be monitored for emergence/worsening of depression, suicidal thoughts/behavior or unusual mood/behavior changes. Study Supported by: Eisai IncDisclosure: Dr. Ettinger has received personal compensation for activities with Eisai Inc. and Upshir-Smith as advisory board member. Dr. Dobrinsky has received personal compensation for activities with Eisai Inc. as an employee. Dr. Yang has received personal compensation for activities with Eisai Inc. as an employee. Dr. Williams has received personal compensation for activities with Eisai Inc. as an employee. Dr. Xing has received personal compensation for activities with Eisai Inc. as an employee. Dr. Fain has received personal compensation for activities with Eisai Inc. as an employee. Dr. Laurenza has received personal compensation for activities with Eisai Inc. as an employee.

Source: Neurology - April 8, 2015 Category: Neurology Authors: Ettinger, A., Dobrinsky, C., Yang, H., Williams, B., Xing, D., Fain, R., Laurenza, A. Tags: Epilepsy/Clinical Neurophysiology (EEG): Epilepsy Therapy Platform Blitz Source Type: research