Co-Adjuvancy of Solasodine & CoQ10 Against High Fat Diet-Induced Insulin Resistance Rats Via Modulating IRS-I and PPAR- γ Proteins Expression
Drug Res (Stuttg) DOI: 10.1055/a-1806-1366Insulin resistance (IR) is a condition in which target cells become insensitive
to normal insulin concentrations in order to deliver glucose. The goal of this
study was to see if solasodine combined with coenzyme Q10 could help rats with
insulin resistance caused by a high-fat diet (HFD) by regulating the expression
of IRS-I and PPAR-γ proteins.One of the six groups (n=6) got a
conventional diet for 16 weeks as a control (normal), the HFD was given to the
other five groups for 16 weeks, which further classified as-one group as HFD
control while others treated with pioglitazone (10 mg/kg),
coenzyme Q10 (50 mg/kg), solasodine (50 mg/kg)
and combination of solasodine and coenzyme Q10i.e. SDQ10 (total
50 mg/kg) for the last 4 weeks orally once daily. Blood and
tissue samples were collected by the end of study period for the biochemical and
histological studies. As a result, HFD fed rats exhibited a significant increase
in food and energy intake, body mass index, kidney and pancreas weight, fasting
glucose, glycosylated haemoglobin, insulin level, liver enzyme ALT and AST and
decrease antioxidant activity of superoxide dismutase and catalase. HFD received
animals also produced a lower level of p-IRS1 and PPAR-y protein expression in
western blot analysis. SDQ10 in...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Khan, Irfan Kumar, Rajesh Prasad, Mahesh Srivastav, Ritesh Kumar Vishwakarma, Vishal Kumar Akhtar, Juber Tags: Original Article Source Type: research
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