Differential effects of cancer modifying agents during radiation therapy on Ehrlich solid tumor-bearing mice: A comparative investigation of metformin and ascorbic acid

CONCLUSIONS: The study added more preclinical evidence on the utility of metformin in cancer treatment during radiotherapy. Metformin was shown to reduce lipid peroxidation in irradiated healthy tissues, increase tumor cytotoxicity, downregulate critical pathways involved in tumor progression and proliferation, and enhance tumor apoptosis. Controlled clinical trials using metformin are highly warranted.PMID:35688071 | DOI:10.1016/j.apradiso.2022.110305

Source: Applied Radiation and Isotopes - June 10, 2022 Category: Radiology Authors: Mennat-Allah Ali Magdy M Khalil Asmaa K Al-Mokaddem Samira H Aljuaydi M M Ahmed Heba M A Khalil Source Type: research