Lipid nanoparticle formulations for optimal RNA-based topical delivery to murine airways

CONCLUSION: LNP formulations enable the delivery of RNA payloads into human airway epithelial cells, and in the murine respiratory system; they can be delivered to nasal mucosa and lower respiratory tract via intranasal delivery. The composition of helper lipids in LNPs crucially modulates transfection efficiencies in airway epithelia, highlighting their importance in effective delivery of therapeutic products for airways diseases.PMID:35688311 | DOI:10.1016/j.ejps.2022.106234

Source: European Journal of Pharmaceutical Sciences - June 10, 2022 Category: Drugs & Pharmacology Authors: A Tam J Kulkarni K An L Li D R Dorscheid G K Singhera P Bernatchez Gsd Reid Kyt Chan D Witzigmann P R Cullis D D Sin C J Lim Source Type: research