Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex

In conclusion, the current findings accentuate the therapeutic potential of celastrol against HFD-induced obese mice via enhanced glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of PDC activity in the skeletal muscle.PMID:35679966 | DOI:10.1016/j.taap.2022.116099

Source: Toxicology and Applied Pharmacology - June 9, 2022 Category: Toxicology Authors: Mohamad Hafizi Abu Bakar Nor Shafiqah Nor Shahril Mohamad Shamil Faris Mohamad Khalid Sharifah Mohammad Khairul Anuar Shariff Thiruventhan Karunakaran Rabeta Mohd Salleh Mohamad NorishamMohamad Rosdi Source Type: research