Food and Drug Administration (FDA) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Patterns of red blood cell utilization: Harnessing electronic health records data from the Information Standard for Blood and Transplant (ISBT) 128 system within the Biologics Effectiveness and Safety (BEST) initiative
This study shows that the ISBT 128 coding system in an EHR environment provides a feasible source for hemovigilance activities.PMID:38689458 | DOI:10.1111/trf.17852 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Joyce Obidi Gayathri Sridhar Gra ça M Dores Barbee Whitaker Carlos H Villa Emily Storch Kinnera Chada Lisa M Schilling Karthik Natarajan Paul Biondich Andrey Soares Matthew Spotnitz Thomas Falconer Saptarshi Purkayastha Nicole L Draper Hui-Lee Wong Matth Source Type: research

Current Status and Perspectives of Therapeutic Antibodies Targeting the Spike Protein S2 Subunit against SARS-CoV-2
Biol Pharm Bull. 2024;47(5):917-923. doi: 10.1248/bpb.b23-00639.ABSTRACTThe global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has devastated public health and the global economy. New variants are continually emerging because of amino acid mutations within the SARS-CoV-2 spike protein. Existing neutralizing antibodies (nAbs) that target the receptor-binding domain (RBD) within the spike protein have been shown to have reduced neutralizing activity against these variants. In particular, the recently expanding omicron subvariants BQ 1.1 and XBB are res...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Yuichiro Yamamoto Tetsuya Inoue Source Type: research

Transcatheter aortic valve replacement in low-risk young population: A double edge sword?
World J Cardiol. 2024 Apr 26;16(4):177-180. doi: 10.4330/wjc.v16.i4.177.ABSTRACTSince the advent of transcatheter aortic valve replacement (TAVR) in 2002, it has now become the default interventional strategy for symptomatic patients presenting with severe aortic stenosis, particularly in intermediate to high-surgical risk patients. In 2019, the United States Food and Drug Administration approved TAVR in low-risk patients based on two randomized trials. However, these breakthrough trials excluded patients with certain unfavorable anatomies and odd profiles. While currently there is no randomized study of TAVR in young pati...
Source: World Journal of Cardiology - May 1, 2024 Category: Cardiology Authors: Sukhdeep Bhogal Akash Batta Source Type: research

Quantitative Brain Amyloid PET
This report provides a high-level summary of the presentations and the discussion. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Jagust, W. J., Mattay, V. S., Krainak, D. M., Wang, S.-J., Weidner, L. D., Hofling, A. A., Koo, H., Hsieh, P., Kuo, P. H., Farrar, G., Marzella, L. Tags: State of the Art Source Type: research

MIRD Pamphlet No. 29: MIRDy90--A 90Y Research Microsphere Dosimetry Tool
90Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration–approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based treatment planning. Several different mathematical models are used to calculate the patient-specific prescribed activity of 90Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, and MIRD dual compartment (partition). Under the auspices of the MIRDsoft initiative to develop community dosimetry software and tools, the body surface area, MIRD single-compart...
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Marquis, H., Ocampo Ramos, J. C., Carter, L. M., Zanzonico, P., Bolch, W. E., Laforest, R., Kesner, A. L., MIRD committee Tags: Basic Science Investigations Source Type: research

Local therapy combined with anti-PD-1 immunotherapy for advanced lung adenocarcinoma: A case report
J Cancer Res Ther. 2024 Apr 1;20(2):739-744. doi: 10.4103/jcrt.jcrt_1600_23. Epub 2024 Apr 30.ABSTRACTLung adenocarcinoma (LUAD) encompasses all lung epithelial cancers except small-cell lung cancer. Although programmed cell death protein 1 (PD-1) inhibitors, such as pembrolizumab, and other Food and Drug Administration-approved immune checkpoint inhibitors, offer new hope for LUAD treatment, LUAD's overall efficacy remains limited. Thus, the combination of immunotherapy with other therapeutic approaches has gained widespread attention. Local therapy is an optimal method for treating many advanced unresectable lung cancers...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Na Wu Xiaoxin Yang Yan Zhai Wei Lu Source Type: research

Deciphering resistance mechanisms and novel strategies to overcome drug resistance in ovarian cancer: a comprehensive review
Oncol Res. 2024 Apr 23;32(5):831-847. doi: 10.32604/or.2024.031006. eCollection 2024.ABSTRACTOvarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for ma...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Effat Alemzadeh Leila Allahqoli Afrooz Mazidimoradi Esmat Alemzadeh Fahimeh Ghasemi Hamid Salehiniya Ibrahim Alkatout Source Type: research

FG-4592 protected haematopoietic system from ionising radiation in mice
Immunology. 2024 Apr 29. doi: 10.1111/imm.13797. Online ahead of print.ABSTRACTIonising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG-4592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system. Mice were peritoneal injected with FG-4592 or normal saline. After irradiation, the survival time, body weight, peripheral blood cell and bone marrow cell (BMC) count, cell apopt...
Source: Immunology - April 30, 2024 Category: Allergy & Immunology Authors: Yuedong Wang Ying Cheng Pei Zhang Daqian Huang Xuanlu Zhai Zhenlan Feng Duo Fang Cong Liu Jicong Du Jianming Cai Source Type: research

Performance characteristics of highly automated HSV-1 and HSV-2 IgG testing
This study is the first large-scale comparison of performance metrics for the Bio-Rad and Roche assays in over 10 years. Our study confirms that there remains room for improvement in HSV serological diagnostic testing-especially in regard to low sensitivities for HSV-1 IgG detection-and highlights that some previously less-studied assays may have better performance metrics than previously considered typical of commercially available HSV-2 IgG assays.PMID:38687020 | DOI:10.1128/jcm.00263-24 (Source: Herpes)
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Katharine H D Crawford Stacy Selke Gregory Pepper Erin Goecker Aniela Sobel Anna Wald Christine Johnston Alexander L Greninger Source Type: research