Food and Drug Administration (FDA) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

FDA Okays First Drug for Scarring From Fatty Liver Disease
The US Food and Drug Administration (FDA) recently approved resmetirom, marketed as Rezdiffra, for adults with nonalcoholic steatohepatitis (NASH) without cirrhosis. NASH is a progressive fatty liver disease that affects up to 8 million people in the US and can cause liver inflammation and scarring, known as fibrosis. Resmetirom, an oral drug that reduces the accumulation of liver fat, can be used along with diet and exercise, which are the standard care for patients with NASH. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 12, 2024 Category: General Medicine Source Type: research

Method development and validation for the estimation of gedatolisib in mouse plasma by tandem mass spectrometry and its application to pharmacokinetics studies
Biomed Chromatogr. 2024 Apr 10:e5878. doi: 10.1002/bmc.5878. Online ahead of print.ABSTRACTA simple and a sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of gedatolisib in mouse plasma. The extraction technique involved a simple precipitation method to extract gedatolisib and idelalisib (internal standard) from mouse plasma. A clean chromatographic separation of gedatolisib and the internal standard was achieved on an Atlantis dC18 column using an isocratic mobile phase (10 mm ammonium formate and acetonitrile; 30:70% v/v, both supplemented with 0.1% formic...
Source: Biomedical Chromatography : BMC - April 11, 2024 Category: Biomedical Science Authors: Vinod A B Arunava Das Source Type: research

Acesulfame potassium upregulates PD-L1 in HCC cells by attenuating autophagic degradation
Biochem Biophys Res Commun. 2024 Apr 9;711:149921. doi: 10.1016/j.bbrc.2024.149921. Online ahead of print.ABSTRACTArtificial sweeteners, which contain no or few calories, have been widely used in various foods and beverages, and are regarded as safe alternatives to sugar by the Food and Drug Administration. While several studies suggest that artificial sweeteners are not related to cancer development, some research has reported their potential association with the risk of cancers, including hepatocellular carcinoma (HCC). Here, we investigated whether acesulfame potassium (Ace K), a commonly used artificial sweetener, indu...
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Dong-Ho Kim Eun-Jun Kwon Keun-Gyu Park Jonghwa Jin Jun-Kyu Byun Source Type: research

Acesulfame potassium upregulates PD-L1 in HCC cells by attenuating autophagic degradation
Biochem Biophys Res Commun. 2024 Apr 9;711:149921. doi: 10.1016/j.bbrc.2024.149921. Online ahead of print.ABSTRACTArtificial sweeteners, which contain no or few calories, have been widely used in various foods and beverages, and are regarded as safe alternatives to sugar by the Food and Drug Administration. While several studies suggest that artificial sweeteners are not related to cancer development, some research has reported their potential association with the risk of cancers, including hepatocellular carcinoma (HCC). Here, we investigated whether acesulfame potassium (Ace K), a commonly used artificial sweetener, indu...
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Dong-Ho Kim Eun-Jun Kwon Keun-Gyu Park Jonghwa Jin Jun-Kyu Byun Source Type: research

Infections Associated with Medtronic Duet External Ventricular Drains - Rhode Island Hospital, Providence, Rhode Island, January 2023-January 2024
MMWR Morb Mortal Wkly Rep. 2024 Apr 11;73(14):312-316. doi: 10.15585/mmwr.mm7314a4.ABSTRACTExternal ventricular drains (EVDs) are medical devices that are inserted into the ventricles of the brain to drain excess fluid, manage intracranial hypertension, monitor intracranial pressure, and administer medications. Unintentional disconnections and breaks or fractures (breaks) of EVDs or associated drainage system components can result in cerebrospinal fluid (CSF) leakage and increased risk for EVD-associated infections. After replacement of Integra Life Sciences EVD systems with Medtronic Duet EVD systems at Rhode Island Hospi...
Source: MMWR Morb Mortal Wkl... - April 11, 2024 Category: Epidemiology Authors: Kevin M Gibas Dianne Auld Stephanie Parente Jean Horoho Leonard A Mermel Source Type: research

Risk of SARS-CoV-2 infection in patients with hematologic diseases receiving tixagevimab/cilgavimab as pre-exposure prophylaxis in most recent Omicron sublineages era
Although the overall mortality during SARS-CoV-2 Omicron variants of concern (VoC) wave might be lower than that seen with other previous VoCs immunocompromised individuals remain at increased the risk of hospitalization and prolonged duration of the infection compared to the general population [1]. Moreover, persons with immunosuppression may experience reduced vaccine immune response with an impaired seroconversion and effectiveness [2]. To address the need to protect these individuals from breakthrough infections and possibly from long-lasting SARS-CoV-2 infections, in December 2021 the combination tixagevimab/cilgavima...
Source: International Journal of Infectious Diseases - April 11, 2024 Category: Infectious Diseases Authors: Alessandra Vergori, Alessandro Cozzi Lepri, Marta Chiuchiarelli, Valentina Mazzotta, Elisabetta Metafuni, Giulia Matusali, Valentina Siciliano, Jessica Paulicelli, Eleonora Alma, Agostina Siniscalchi, Simona Sica, Elisabetta Abruzzese, Massimo Fantoni, An Tags: Short Communication Source Type: research