Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy
Biol Chem. 2024 Apr 24. doi: 10.1515/hsz-2024-0023. Online ahead of print.ABSTRACTIntegration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here, we applied a machine learning-based data integration to distinguish patho-phenotypic features at the subcellular level for dilated cardiomyopathy (DCM). We employed a human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of a DCM mutation in the sarcomere protein troponin T (TnT), TnT-R141W, compared to isogenic healthy (WT) control iPSC-CMs. ...
Source: Biological Chemistry - April 23, 2024 Category: Chemistry Authors: Ruheen Wali Hang Xu Cleophas Cheruiyot Hafiza Nosheen Saleem Andreas Janshoff Michael Habeck Antje Ebert Source Type: research
18 β-glycyrrhetinic acid alleviates radiation-induced skin injury by activating the Nrf2/HO-1 signaling pathway
In conclusion, our results suggest that 18β-GA reduces intracellular ROS production and apoptosis by activating the Nrf2/HO-1 signaling pathway, leading to amelioration of radiation dermatitis.PMID:38598859 | DOI:10.1515/hsz-2023-0200 (Source: Biological Chemistry)
Source: Biological Chemistry - April 10, 2024 Category: Chemistry Authors: Zeng Wang Ruiqing Chen Junying Chen Li Su Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
