Towards correlative archaeology of the human mind
Biol Chem. 2023 Oct 12. doi: 10.1515/hsz-2023-0199. Online ahead of print.ABSTRACTRetracing human cognitive origins started out at the systems level with the top-down interpretation of archaeological records spanning from man-made artifacts to endocasts of ancient skulls. With emerging evolutionary genetics and organoid technologies, it is now possible to deconstruct evolutionary processes on a molecular/cellular level from the bottom-up by functionally testing archaic alleles in experimental models. The current challenge is to complement these approaches with novel strategies that allow a holistic reconstruction of evolut...
Source: Biological Chemistry - October 11, 2023 Category: Chemistry Authors: Lukasz Piszczek Joanna Kaczanowska Wulf Haubensak Source Type: research
The good or the bad: an overview of autoantibodies in traumatic spinal cord injury
Biol Chem. 2023 Oct 3. doi: 10.1515/hsz-2023-0252. Online ahead of print.ABSTRACTInfections remain the most common cause of death after traumatic spinal cord injury, likely due to a developing immune deficiency syndrome. This, together with a somewhat contradictory development of autoimmunity in many patients, are two major components of the maladaptive systemic immune response. Although the local non-resolving inflammation in the lesioned spinal cord may lead to an antibody formation against autoantigens of the injured spinal cord tissue, there are also natural (pre-existing) autoantibodies independent of the injury. The ...
Source: Biological Chemistry - October 3, 2023 Category: Chemistry Authors: Annika Guntermann Katrin Marcus Caroline May Source Type: research
