Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Study of two glycosyltransferases related to polysaccharide biosynthesis in < em > Rhodococcus jostii < /em > RHA1
Biol Chem. 2024 Mar 15. doi: 10.1515/hsz-2023-0339. Online ahead of print.ABSTRACTThe bacterial genus Rhodococcus comprises organisms performing oleaginous behaviors under certain growth conditions and ratios of carbon and nitrogen availability. Rhodococci are outstanding producers of biofuel precursors, where lipid and glycogen metabolisms are closely related. Thus, a better understanding of rhodococcal carbon partitioning requires identifying catalytic steps redirecting sugar moieties to storage molecules. Here, we analyzed two GT4 glycosyl-transferases from Rhodococcus jostii (RjoGlgAb and RjoGlgAc) annotated as α-gluc...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Antonela Estefania Cereijo Mar ía Victoria Ferretti Alberto Alvaro Iglesias H éctor Manuel Álvarez Mat ías Damian Asencion Diez Source Type: research
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation
Biol Chem. 2024 Mar 18. doi: 10.1515/hsz-2024-0018. Online ahead of print.ABSTRACTThe linkage between low-density lipoprotein receptor-related protein (LRP)1-mediated metabolism of apolipoprotein (apo) E-containing lipoproteins (apoE-LP) and the lipopolysaccharide (LPS)-induced inflammatory response contributes to the pathogenesis of sepsis; however, the underlying mechanisms are unclear. Therefore, in this study, the effects of apoE-LP and their constituents on the mRNA expression of interleukin (IL)-6 and LRP1 were evaluated using a culture system of human fibroblasts supplemented with LPS and apoE-containing emulsion pa...
Source: Biological Chemistry - March 15, 2024 Category: Chemistry Authors: Shogo Akahane Hiroto Matsuura Takahiro Kaido Yoko Usami Nau Ishimine Takeshi Uehara Kazuyoshi Yamauchi Source Type: research
Yeast Bxi1/Ybh3 mediates conserved mitophagy and apoptosis in yeast and mammalian cells: convergence in Bcl-2 family
Biol Chem. 2024 Mar 12. doi: 10.1515/hsz-2023-0359. Online ahead of print.ABSTRACTThe process of degrading unwanted or damaged mitochondria by autophagy, called mitophagy, is essential for mitochondrial quality control together with mitochondrial apoptosis. In mammalian cells, pan-Bcl-2 family members including conical Bcl-2 members and non-conical ones are involved in and govern the two processes. We have illustrated recently the BH3 receptor Hsp70 interacts with Bim to mediate both apoptosis and mitophagy. However, whether similar pathways exist in lower eukaryotes where conical Bcl-2 members are absent remained unclear....
Source: Biological Chemistry - March 11, 2024 Category: Chemistry Authors: Yuying Wang Zhiyuan Hu Maojun Jiang Yanxin Zhang Linjie Yuan Ziqian Wang Ting Song Zhichao Zhang Source Type: research
