Gynecological Bleeding in Women with Congenital Bleeding Disorders: A Comprehensive Cohort from Iran
In this study, we aim to evaluate gynecological bleeding particularly menorrhagia among Iranian women patients with inherited bleeding disorders admitted to the Iranian Comprehensive Hemophilia Care Center (ICHCC). (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 29, 2024 Category: Hematology Authors: Alireza Zafarani, Elnaz Ghodratnia, Mohammad Reza Amirzargar, Yasaman Poriafar, Shadi Tabibian Source Type: research
Effect of Apheresis Plasma Donation on Plasma Uric Acid Levels, the Lipid Profile, and Major Plasma Proteins in Plasma Donors in China: A Multicenter, Prospective Cohort Study
Abnormal plasma uric acid (UA) levels, the lipid profile, and plasma proteins in blood are associated with a range of adverse health outcomes. This multicenter, prospective cohort study aimed to determine the possible effects of multiple apheresis plasma donations on plasma UA levels, the lipid profile, and major proteins in plasma donors. Participants were enrolled from 1 April 2021 to 31 August 2022. When their plasma UA (men:>420 µmol/L, women:>360 µmol/L) and/or lipid levels (total cholesterol [TC]: ≥6.2mmol/L, triglycerides [TGs]: ≥2.3mmol/L, low-density lipoprotein cholesterol: ≥4.1mmol/L, or high-density lip...
Source: Transfusion and Apheresis Science - April 29, 2024 Category: Hematology Authors: Qing Liu, Fengjuan Liu, Pan Sun, Xi Du, Liyuan Zhu, Jun Xu, Lu Cheng, Yaojing Huang, Chunyan Huang, Jielin Chen, Zhibo Wang, Aihong Lu, Yikuan Zhu, Huan Huang, Junli Huang, Jufeng Pan, Li Ma, Zongkui Wang, Changqing Li Source Type: research
Serology and Molecular genetic analysis of two unrelated individuals with the Same Novel CisAB Blood Type
This study aims to report two unrelated individuals with the same novel CisAB blood type and confirm this rare blood type using a comprehensive approach that combines serological and molecular biology techniques. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 25, 2024 Category: Hematology Authors: Tongtong Li, Yongqiang Shan, Xinhua Zhou, Ying Zhao, Lina Wu, Xian Huang, Yang Yang, Jinhui Xie, Jinghui Chong Source Type: research
Successful treatment of concurrent cold agglutinin disease and myelodysplastic syndrome
Herein, we describe a case of severe anemia presenting with myelodysplastic syndrome with cold agglutinin disease that was successfully treated by a moderate dose of steroids followed by cyclosporine. In patients with myelodysplastic syndrome, autoimmunity in erythroid cells is occasionally demonstrated, and autoimmune hemolytic anemia is seen in some patients. However, hemolytic anemia with cold agglutinin in patients with myelodysplastic syndrome is less common, and the effect of corticosteroids for autoimmune hemolytic anemia caused by cold agglutinin is thought to be limited. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 25, 2024 Category: Hematology Authors: Rie Tabata, Chiharu Tabata Source Type: research
Determination of optimum levels of binding antibody units (BAU) of new quantitative chemiluminescent immuno-assay (CLIA) in COVID-19 vaccinated volunteer blood donors
This study was undertaken to determine optimum levels of binding antibody units (BAU/ml) in new quantitative chemiluminescent assay (CLIA) that corresponded to neutralizing potential (30% inhibition) of sVNT assay. Methods: Ninety-one blood samples were analyzed by CLIA and sVNT assays. Test samples (n=75) were collected from blood donors post-2nd vaccination dose, while control samples (n=16) were archived pre-COVID donor samples. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 24, 2024 Category: Hematology Authors: Aseem Kumar Tiwari, Geet Aggarwal, Pratibha Kale, Neeti Yadav, Virendra Kumar, Gargi Singh, K. Cheirmaraj, K. Krishnan Source Type: research
Focus on: Prognostic scores to predict stem cell mobilization
Autologous stem cell transplantation (ASCT) still represents a mainstay of treatment for multiple (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 23, 2024 Category: Hematology Authors: F. Olivieri A (Ancona- I) Saraceni, A. De Luca Source Type: research
Outpatient Hospitalist-Run Procedure Service Bridges the Gap in Oncology Care
Hospitalist-run procedure teams enable expedited care in the inpatient setting. However, wait times for outpatient interventional radiology (IR) are long at our institution. Our study thus aims to compare the safety and wait times between procedural teams and IR placement of outpatient temporary hemodialysis catheters (THDC) for patients undergoing Chimeric antigen receptor T-cell (CAR-T) therapy apheresis.A retrospective chart review was conducted on all patients receiving outpatient THDC for CART therapy from August 2019 until November 2022. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 21, 2024 Category: Hematology Authors: Ghadi Ghanem, Hsin Hsiang Clarence Tsai, Catherine Durant, Gary S. Feigenbaum, Alexandra Milin Glaeser Source Type: research
Novel approaches for hematopoietic stem cell mobilisation and collection need to be assessed for qualification and validation to accomplish the proper requirements of their intended purpose
The second stem cell (SC) mobilization issue has included four manuscripts related to different aspects which are thought to be critical in the hematopoietic SC collection procedure. The first paper by Worel et al. is focused on the optimal management of poor mobilisers, while the second one by Olivieri et al. has discussed the role played by prognostic scores to predict the amount of HSC mobilized in the peripheral blood. It is well known that the success of the autologous SCT(ASCT) procedure is strictly related to an adequate HSC collection. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 20, 2024 Category: Hematology Authors: F Lanza, G. Marconi Source Type: research
Guest Editor ’s Bio
Francesco Lanza is a Professor of Hematology at the University Medical School of Bologna- Alma Mater Studiorum and head of the Hematology and Phase 1 trial Unit in Ravenna, Italy,and director of the Stem cell Transplant Network in the Romagna Region. He is Senior Editor of Transfusion and Apheresis Science, and, as such, earlier presented Part 1 of this Theme (in vol 62, issue 6, cover date, December 2023). His main research activity focuses on stem cell transplantation, acute leukemia, and stem cell manipulation and processing. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 20, 2024 Category: Hematology Authors: Francesco Lanza Source Type: research
Editorial Comments: looking for some innovative diagnostic or developmental research studies that might influence our laboratory and clinical decision-making
For this issue, I have invited two leading experts to share the outcome of their innovative ongoing studies on the advancement of in vivo assessment of RBC and platelet function testing in specialized emergency cases. Prof. Jason Acker ’s team reports on two interrelated topics that are exceedingly relevant to modern Transfusion Medicine. The first manuscript is aimed at the influence of RBC quality in red cell concentrates on vascular redox homeostasis and associated redox signalling measures which are novel in vivo quality mea surements of red cell concentrates and reflect future directions in post-transfusion redox an...
Source: Transfusion and Apheresis Science - April 18, 2024 Category: Hematology Authors: Jerard Seghatchthiian Source Type: research
Mobilization and collection of CD34 + cells in patients with globin disorders: Providing the starting material to manufacturers of autologous gene therapies
Globin gene disorders are a group of inherited diseases that result in altered production, structure or function of hemoglobin. The prevalence of these chronic ailments is significantly related to genetic and ethnic backgrounds, with a high fraction of patients living in low- to medium-income countries [1]; however, and as a result of migrations over centuries, a smaller fraction of patients reside in high-income countries. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 17, 2024 Category: Hematology Authors: Christian Chabannon, Sandrine Visentin, Ang éla Granata, Isabelle Thuret Source Type: research
A perspective on exogenous redox regulation mediated by transfused RBCs subject to the storage lesion
Granted with a potent ability to interact with and tolerate oxidative stressors, RBCs scavenge most reactive oxygen and nitrogen species (RONS) generated in circulation. This essential non-canonical function, however, renders RBCs susceptible to damage when vascular RONS are generated in excess, making vascular redox imbalance a common etiology of anemia, and thus a common indication for transfusion. This accentuates the relevance of impairments in redox metabolism during hypothermic storage, as the exposure to chronic oxidative stressors upon transfusion could be exceedingly deleterious to stored RBCs. (Source: Transfusio...
Source: Transfusion and Apheresis Science - April 17, 2024 Category: Hematology Authors: Nishaka William, Jason P. Acker Source Type: research
Graft collection by apheresis and graft composition
Ever since Hematopoietic Stem Cells (HSCs) were first identified in blood [1] there has been great interest in developing alternative methods to bone marrow harvesting under general anesthesia. In particular, the introduction of techniques for extensive collection of blood cells by leukapheresis and the knowledge of factors affecting stem cell concentration in blood, such as a great stem cell output after chemotherapy [2], growth factor administration [3] [Granulocyte Colony Stimulating Factor (G-CSF), Plerixafor] or their combination, has allowed, nowadays, the replacement of bone marrow harvests with blood stem cell coll...
Source: Transfusion and Apheresis Science - April 17, 2024 Category: Hematology Authors: Luca Pierelli, Anna Capalbo Source Type: research
Impact of ABO blood group on mortality in trauma patients: A systematic review
Hemorrhage is a significant cause of death in trauma patients. There is evidence that individuals with blood group O have higher rates of non-traumatic haemorrhage. It has been suggested that blood group O may be associated with higher mortality in trauma, however existing evidence is limited and conflicting. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 17, 2024 Category: Hematology Authors: Andrew Follows, Antonia Round Source Type: research
Mobilization and collection of cd34+ cells in patients with globin disorders: providing the starting material to manufacturers of autologous gene therapies
Globin gene disorders are a group of inherited diseases that result in altered production, structure or function of hemoglobin. The prevalence of these chronic ailments is significantly related to genetic and ethnic backgrounds, with a high fraction of patients living in low- to medium-income countries [1]; however, and as a result of migrations over centuries, a smaller fraction of patients reside in high-income countries. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 17, 2024 Category: Hematology Authors: Christian Chabannon, Sandrine Visentin, Ang éla Granata, Isabelle Thuret Source Type: research
