The Turkish Perspective on Apheresis Activity: The Turkish Apheresis Registry Report
Therapeutic apheresis is an extracorporeal treatment that selectively removes abnormal cells or harmful substances in the blood that are associated with or cause certain diseases. During the last decades the application of therapeutic apheresis has expanded to a broad spectrum of hematological and non-hematological diseases due to various studies on the clinical efficacy of this procedure. In this context there are more than 30 centers performing therapeutic apheresis and registered in the apheresis database in Turkey. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Duzgun Ozatli, Asl ı Odabaşı Giden, Mehmet Ali Erkurt, Serdal Korkmaz, Semih Basci, Turgay Ulas, Burhan Turgut, Tugce Nur Yigenoglu, Tuba Hacibekiroglu, Abdulkadir Basturk, Mehmet Sinan Dal, Sinem Namdaroglu, Fehmi Hindilerden, Sibel Kabukcu Hacioglu, Tags: Review Source Type: research
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Dr. Vrielink (1958) was educated at the University of Amsterdam in Medicine and wrote his thesis (1996) on the ‘Laboratory diagnosis of viruses transmitted by blood transfusion’. He has worked since 1985 as a transfusion and apheresis medicine specialist at Sanquin Blood Supply Foundation, the national blood transfusion service in the Netherlands. Dr. Vrielink has published many articles and chapters in internationally recognized journals and books on various subjects. Dr. Vrielink is the initiator of (inter)national courses in the field of apheresis for physicians and nurses and since 2013, has trained almost 1,000 ap...
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Hans Vrielink Tags: Editorial Source Type: research
Special Issue proceedings of the 17th International of the World Apheresis Association A Message from Dr. Gail Rock co-editor in chief
In September of this year the World Apheresis Association held the 17th International Congress in Istanbul. This was a long-awaited meeting with the last meeting being held in 2016 in Paris. The previously scheduled meeting for 2020 in Istanbul was postponed due to the Covid pandemic and so it was with great enthusiasm that we met, in person, for the first time in many years, in the amazing city of Istanbul from September 14 to 17 this past year. More than four hundred people were registered at the meeting representing thirty one countries from around the world and the opportunity for exchanging information on her internat...
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Gail Rock Source Type: research
Clinical use of car t-cells in treating acute lymphoblastic leukemia
Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape for adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). However CAR T-cell therapy of R/R T-ALL has unique challenges, such as the lack of specific tumor antigens, cell fratricide and T cell aplasia, in comparison with that of R/R B-ALL. Despite promising therapeutic outcomes in R/R B-ALL, application of this therapy is limited by high relapse rates and immunological toxicities. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Serdal KORKMAZ Tags: Review Source Type: research
Are we donating iron? Impact of apheresis on ferritin
Iron deficiency due to donation by apheresis has been known for decades [1], but data on this topic are more limited compared to that on whole blood donors. Because of the increasing trend of both the usage of platelets components (e.g. in the US, an almost 16% increase in 2019 compared to 2017 [2]) and the rising activity of source plasma collection [3], the number of healthy individuals undergoing automated blood donations is predicted to significantly grow. At the same time, the protection of blood donors from iron deficiency has become one of the major challenges in donor care [4] with the aim not to harm healthy volun...
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Laura Infanti Source Type: research
Vascular Access for Apheresis: State of the Art
The vascular access is a crucial issue when performing a therapeutic apheresis treatment, therefore an updated knowledge of the available vascular access devices is recommended. There are not many vascular access devices designed for apheresis, but potentially useful devices may be found on the market. One of the most useful improvements in an apheresis unit is the use of an ultrasound system for cannulating peripheral veins. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Mar ía-Jesús Mustieles, Miquel Lozano Source Type: research
Nurses perspective of apheresis in SARS-CoV-2 infected patients
The COVID-19 pandemic had world wide an enormous impact on the complete global population and all daily activities. Not only in the work related situation, but also in the private. Fear to become infected, or infect third parties (family and other patients) is present, and in the same time organizing an apheresis unit country wide is a challenge. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Linda Tjoelker en Hans Vrielink Source Type: research
Basics of apheresis and equipment
Apheresis is a method of obtaining one or more blood components by machine processing of whole blood in which the residual components are returned to the donor or patient during or at the end of the process. To achieve this, the desired blood component is separated from the whole blood using centrifugal, filtration and or adsorption techniques. Although the apheresis equipment from various manufacturers look from the outside very different, the working is rather similar with separation in a one-use disposable, connected with bacterial filters to the machine, and various safety features to achieve optimal safety for donor /...
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Hans Vrielink, Marleen M. Neyrinck Tags: Review Source Type: research
Fibroblastic growth factor 23 linking iron and bone metabolism. Hypothesis on how FGF23 is effected by blood donation
Fibroblastic growth factor 23 (FGF23) is a circulating hormone mainly secreted by the osteocytes in the bone. Around 2000, after decades of research, FGF23 was discovered as being the “circulating factor phosphatonin” that causes the symptoms in patients with autosomal dominant hypophosphatemic rickets (ADHR). This disease is characterized by hypophosphatemia and hypophosphaturia resulting in growth retardation, bone deformities and rickets. Patients with ADHR develop flares of hypophosphatemia that coincidence with the development of iron deficiency and thus microcytic anemia [1,2]. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Kaatje le Poole, Hans Vrielink Tags: Review Source Type: research
Plasmapheresis in ABO incompatible kidney transplant
In patients with an end-stage renal disease, dialysis a or kidney transplant are required to prolong live. For survival of the transplanted kidney, besides the HLA-system, the ABO blood type of donor and patient is also of importance. When the donor organ is derived from a living donor, time can be available prior to the transplant to reduce blood type AB antibodies in case of ABO major incompatibility between organ donor and recipient by double filtration apheresis. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Hans Vrielink, Kaatje le Poole Source Type: research
Mathematics of Apheresis
Mathematics is related to apheresis medicine. The safety of donor and patient in taking blood components is utterly important. Knowledge of total blood and plasma volume is needed and have to be calculated. By increasing quality, the safety of not only the donor and patient, but also the operator will increase, as well as the efficiency of operating an apheresis collection facility. Various concepts, formulas and calculations methods and their significance in apheresis are given in this paper. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Linda Tjoelker, Marleen Neyrinck, Hans Vrielink Tags: Review Source Type: research
Basic Principles of Therapeutic Plasma Exchange
Therapeutic plasma exchange is a method of treatment for clinical conditions that represent diverse fields of medicine. The rationale for this mode of therapy is based on sound mathematical modeling of the synthesis and removal of large molecules, usually proteins, from the circulation. The basic assumptions underlying therapeutic plasma exchange are that a clinical illness is caused by, or related to, a pathogenic substance in the plasma, and that removing that substance from the plasma will alleviate the patient ’s illness. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Robert Weinstein Tags: Review Source Type: research
Gene Therapy Approaches for Sickle Cell Anemia
Sickle cell disease (SCD) has a widely variable clinical course; some of them are severely affected in childhood while in others major damage does not manifest until adulthood. There is no test that can be used to predict the disease course. The best predictor of SCD severity is a patient ’s course to date [1]. Patients’ quality of life is low and life expectancy is relatively short, nearly 50 years, even newly developed treatments such as iron chelating and disease modifying agents. The only curative treatment option is allogeneic stem cell transplantation (Allo-SCT), but only o ne fifth of the patients have matched s...
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Turgay Ulas, Mehmet Sinan Dal Source Type: research
Extracorporeal photopheresis in conditions of autoimmunity
Autoimmune disorders (AID) are chronic conditions that involve the loss of immunological tolerance to self-antigens, and result in systemic or tissue-specific damage. Current treatment regimens for AID are often nonspecific and involve long-term administration of immunosuppressive agents such as corticosteroids, calcineurin inhibitors, and cytotoxic chemotherapeutics[1]. While effective, these medications render the patient vulnerable to opportunistic infections, as well as increasing long-term risk of secondary malignancy[2]. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Christopher Webb Tags: Review Source Type: research
Apheresis in pediatric patients: Current differences and difficulties
Pediatric patients require tailored therapy adjusted to their age and condition and someone to stand for their rights as they are politically vulnerable. Apheresis procedures performed on the pediatric patient group is challenging like elderly or pregnant patients. Differences from adult group and difficulties during the apheresis procedure may be discussed in four major groups: lack of evidence for apheresis in pediatrics, rapidly changing body weight and height alongside small proportions of newborns and infants, continuous embodiment and development of organ systems forcing health care providers to pay extra attention f...
Source: Transfusion and Apheresis Science - February 24, 2023 Category: Hematology Authors: Ba şak Adaklı Aksoy Source Type: research
