International Forum: The WAA next Congress
Following a very successful 17th International Congress held jointly with the European Society for Hemapheresis and the Turkish Society for Hematological Rare Diseases last year in Istanbul in September, the WAA has sent out a request for proposals from organizations who may wish to hold the next Congress in 2024. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 10, 2023 Category: Hematology Authors: Gail Rock Tags: Editorial Source Type: research
Do cord blood CD34 cells stay the same or change after expansion: A comprehensive analysis of gene expression results before and after seven days of cell culture.
Hematopoietic stem cell transplantation is used to treat hematopoietic malignancies and bone marrow failure syndromes. Due to the difficulties of using these cells isolated from the bone marrow, an additional source for receiving essential hematopoietic cells is umbilical cord blood. But the main problem with using the umbilical cord is its insufficient blood volume. The ex-vivo reproductive system of hematopoietic stem cells can overcome this problem that has the ability for Transplantation and hematopoiesis in the long term. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 7, 2023 Category: Hematology Authors: Mohammad Hashemi Bahramani, Atoosa Gharib, Masoud Soeimani, Mahnaz Rabiei Source Type: research
Prevalence of blood group antigens among regular blood donors: A single center study from South India with a review of national literature
The antigen frequencies vary across different regions and ethnic groups. Hence, we aimed to study the prevalence of blood group antigens in our population and to systemize the zone-wise prevalence of the same across India. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 2, 2023 Category: Hematology Authors: Deepika Chenna, Isha Polavarapu, Shamee Shastry Source Type: research
Prevalence of Blood Group Antigens among regular blood donors: A single centre study from South India with a Review of national literature
A database of blood group phenotype of donors not only helps in timely provision of red cell components to required patients but also helps in understanding the phenotype frequencies of that population. Blood group antigen frequencies are not the same among all the populations. It varies across different regions as well as ethnic groups. The possibility of an individual developing an antibody after exposure to a red cell antigen which an individual lacks depends on various factors like age, immune status, disease state of the individual, immunogenicity of the antigen, duration of transfusion therapy, environmental factors ...
Source: Transfusion and Apheresis Science - June 2, 2023 Category: Hematology Authors: Deepika Chenna, Isha Polavarapu, Shamee Shastry Source Type: research
Editorial Board
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 1, 2023 Category: Hematology Source Type: research
Association of blood donor characteristics with in vitro platelet storage properties
The study was planned to determine the association of blood donor characteristics with in vitro quality of platelets. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 1, 2023 Category: Hematology Authors: Ravneet Kaur, Kshitija Mittal, Rajbir Kaur Cheema, Seema Gupta, Tanvi Sood, Paramjit Kaur Source Type: research
Aspects of laboratory characteristics, analysis of alloimmunization, and searching for predictors related to survival in patients with Autoimmune Hemolytic Anemia
Autoimmune hemolytic anemia (AIHA) is characterized by hemolysis caused by autoantibodies. However, many patients do not respond to therapies and may have an unfavorable outcome. It has been hypothesized that patients with AIHA and alloantibodies have a lower survival compared to patients with this disease and without alloimmunization. To this end, the clinical and laboratory profile was described and sought to identify features associated with survival in patients with AIHA. This is a single-site retrospective observational study that included patients (children, adolescents, adults and elderly) diagnosed with AIHA from J...
Source: Transfusion and Apheresis Science - May 25, 2023 Category: Hematology Authors: Giane Durigon, Leo Sekine, Juliana Pires Marafon Franz, Laura Maria Fogliatto, Lucia Mariano da Rocha Silla Source Type: research
Bleeding Disorder of Unknown Cause: Results From Iranian Study
This study aims to document the clinical characteristics and proportion of patients with BDUC in the Iranian Comprehensive Hemophilia Care Center (ICHCC) one of the referral centers for diagnosis of congenital bleeding disorder in Iran. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 23, 2023 Category: Hematology Authors: Alireza Zafarani, Elnaz Ghodratnia, Mohammad Reza Amirzargar, Mohammad Mahmoudi, Mahsa Taghavi-Farahabadi, Fatemeh Tavangar, Babak Abdolkarimi, Shadi Tabibian Source Type: research
Efficacy of allogeneic platelet growth factors in actinic cystitis: the resolution of trouble?
Actinic cystitis is a severe complication after radiotherapy for prostate cancer. It is a chronic inflammatory process that leads to an alteration of bladder mucosa with formation of petechiae and subsequently hematuria. Actinic cystitis responds poorly to medical treatment, with a heavy burden on patients ’ quality of life. Patients with refractory hematuria may undergo cystectomy in the attempt to control bleeding. We conducted a prospective study to evaluate the effectiveness of the allogeneic platelet growth factors for actinic cystitis. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 22, 2023 Category: Hematology Authors: Luciano Abbruzzese, Elisa Nescis, Elisabetta Turco, Pasqualina Amoroso, Giancamillo Carluccio Source Type: research
Cryopreservation and Storage Patterns of Hematopoietic Progenitor Stem Cells for Multiple Myeloma
Autologous hematopoietic stem cell transplantation (HCT) has been a standard of care treatment for eligible patients with newly diagnosed multiple myeloma (MM). Guidelines generally recommend hematopoietic progenitor cell (HPC) harvest for two potential HCT. There is a paucity of data reporting use of such collections in the era of novel approved therapies. In this single-center retrospective study, our goal was to determine the HPC utilization rate and costs associated with leukocytapheresis, collection, storage, and disposal to guide future HPC collection planning. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 20, 2023 Category: Hematology Authors: Cara L. Benjamin, Shreena Desai, Denise Pereira, Amer Beitinjaneh, Antonio Jimenez, Mark Goodman, Lazaros Lekakis, Jay Spiegel, Krishna V. Komanduri, Trent P. Wang Source Type: research
Congenital Thrombotic Thrombocytopenic Purpura Masquerading As Vitamin B12 Deficiency
Congenital thrombotic thrombocytopenic purpura (CTTP), also called Upshaw-Schulman syndrome (USS), is a rare autosomal recessive disorder resulting from the deficiency of the ADAMTS13. CTTP is characterized by the formation of platelet-rich thrombi in small vessels of multiple organs, resulting in thrombocytopenia and microangiopathic hemolytic anemia, eventually leading to organ failure. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 15, 2023 Category: Hematology Authors: Deedar Nanjiani, Sohail Kumar, Nitik Sharma, Sundus Nasim, Dua Azim, Oam Parkash Source Type: research
Immunohematological Challenges In COVID Infected Patients
Several autoimmune disorders have been reported to be related with COVID infection. In continuation to these autoimmune phenomenon, autoimmune hemolytic anaemia (AIHA) also has been noted in COVID infected patients. The aim of the study was to find out the prevalence of red cell alloimmunization, ABO discrepancy and positive direct antiglobulin test (DAT) results in COVID infected patients hospitalised in a tertiary care centre in North India. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 15, 2023 Category: Hematology Authors: Prashant Pandey, Saikat Mandal, Shweta Ranjan, Divya Setya, Supriya Kumari, Arghyadeep Marik Source Type: research
Challenges in the transfusion management of a 15-month-old pediatric patient with Bombay blood group phenotype
Bombay blood group phenotype is often mistyped as O group which can lead to hemolytic transfusion reactions. There are a very few case reports of Bombay blood group phenotype in pediatric age group. Herein, we report an interesting case of Bombay blood group phenotype in a fifteen-month-old pediatric patient who presented with features of raised intracranial pressure and required an emergency surgery. The Bombay blood group was detected on detailed immunohematology work up which was further confirmed by molecular genotyping. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 12, 2023 Category: Hematology Authors: Sheetal Malhotra, Mansi Mulay, Harita Maru, Ashish Jain, Paritosh Sharma, Swati Kulkarni, Ratti Ram Sharma Tags: Case Report Source Type: research
Spanish registry of thrombotic thrombocytopenic purpura (REPTT): data evidence and new developments
Immuno Thrombotic thrombocytopenic purpura (iTTP) is a rare and potentially fatal disorder characterized by systemic microvascular thrombosis because of a severe deficiency of ADAMTS13. It is difficult to generate knowledge about TTP because of its low incidence and the lack of clinical trials. Most of the evidence on diagnosis, treatment, and prognosis has been generated from real-world data registries.In 2004, the Spanish Apheresis Group (GEA) implemented the Spanish registry of TTP (REPTT) with 438 patients suffering 684 acute episodes in 53 hospitals up to January 2022. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 11, 2023 Category: Hematology Authors: Mar ía Eva Mingot-Castellano, Cristina Pascual Izquierdo, Julio del Rio Garma Source Type: research
Characterizing the Process of Urgent Referrals and Transfers to a Large Tertiary Care Apheresis Centre in Ontario:: A retrospective database review
Therapeutic plasma exchange (TPE) and red blood cell exchange (RBCX) are life-saving apheresis procedures offered in 7 Ontario hospitals. Most referrals are directed by CritiCall Ontario (CritiCall), a 24/7 service funded by the Ontario Ministry of Health and Long-Term Care. We used CritiCall data to examine referral requests, acceptances, and transfers for urgent apheresis to our centre. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 10, 2023 Category: Hematology Authors: Kristine Matusiak, Kevin H.M. Kuo, Andrew Binding, David Barth, Christopher J. Patriquin Source Type: research
