Demographics and appropriateness of cellular blood component Irradiation practices; Ambispective analysis from a tertiary care center
This study was undertaken to highlight these shortcomings, and generate data for development of institutional guidelines. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - February 1, 2023 Category: Hematology Authors: Charumathy Arjunan, Dheeraj Khetan, Vasundhara Singh, Priti Elhence, R K Chaudhary, Anurag Kumar Source Type: research
Intermediate-dose cyclophosphamide and bortezomib for PBSC mobilization in multiple myeloma
Although the incorporation of bortezomib into induction regimens has improved, response rates in patients with multiple myeloma (MM), the role of bortezomib in the, peripheral blood stem cell (PBSC) mobilization remains unclear. We assessed the, PBSC mobilization efficacy, safety, and disease response of intermediate-dose, cyclophosphamide and bortezomib in the PBSC mobilization. Twenty-one patients with, newly diagnosed MM were enrolled in a phase II, non-randomized study that used, bortezomib (1.3 mg/m2/day on days 1, 4, 8, and 11) and intermediate-dose, cyclophosphamide (2 g/m2/day on days 2, 3) (Bor-ID-CY). (Source:...
Source: Transfusion and Apheresis Science - January 31, 2023 Category: Hematology Authors: Aiko Sawazaki, Chiharu Sugimori, Masaki Yamaguchi, Shinji Nakao Source Type: research
33Intermediate-dose cyclophosphamide and bortezomib for PBSC mobilization in multiple myeloma
Although the incorporation of bortezomib into induction regimens has improved, response rates in patients with multiple myeloma (MM), the role of bortezomib in the, peripheral blood stem cell (PBSC) mobilization remains unclear. We assessed the, PBSC mobilization efficacy, safety, and disease response of intermediate-dose, cyclophosphamide and bortezomib in the PBSC mobilization. Twenty-one patients with, newly diagnosed MM were enrolled in a phase II, non-randomized study that used, bortezomib (1.3mg/m2/day on days 1, 4, 8, and 11) and intermediate-dose, cyclophosphamide (2g/m2/day on days 2, 3) (Bor-ID-CY). (Source: Tran...
Source: Transfusion and Apheresis Science - January 31, 2023 Category: Hematology Authors: Aiko Sawazaki, Chiharu Sugimori, Masaki Yamaguchi, Shinji Nakao Source Type: research
Polyclonal immunoglobulins for covid-19 pre-exposure prophylaxis in immunocompromised patients
Immunocompromised patients remain at high risk of COVID-19 morbidity and mortality. After recent Omicron sublineages gained full resistance to Evusheld ™, they are left without effective pre-exposure prophylaxis. We review here arguments to support the growing role of regular immunoglobulin (IG) infusions at protecting against COVID-19. Since there is evidence for neutralizing antibody titers approaching the ones seen in hyperimmune sera, and sin ce some categories of patients at risk for COVID-19 progression are already under preexposure prophylaxis with IG, this cost cost-effective strategy should be urgently investiga...
Source: Transfusion and Apheresis Science - January 29, 2023 Category: Hematology Authors: Daniele Focosi, Massimo Franchini Source Type: research
Association of crystalloid fluid infusion with intravascular hemolysis and organ dysfunction in hematopoietic stem cell transplant patients
Endothelial cell activation and injury is common after hematopoietic stem cell transplant (HSCT) and is associated with many post-transplant complications. An underexplored mechanism of endothelial cell damage in this population is the infusion of normal saline (NS, 0.9% sodium chloride) and other crystalloids, as NS use is associated with adverse outcomes in other patient populations. We hypothesized that the infusion of unbalanced crystalloids during HSCT may lead to changes in biomarkers commonly associated with red blood cell (RBC) hemolysis in patients before and after infusion, and that markers of endothelial and end...
Source: Transfusion and Apheresis Science - January 12, 2023 Category: Hematology Authors: Melissa R. Holloway, Thomas Fountaine, Kelly Henrichs, Tate Feeney, Jeffrey Andolina, Kristen O ’Dwyer, Jane Liesveld, Neil Blumberg, Eric Huselton Source Type: research
Identification of two novel FUT1 mutations in people with Bombay phenotype from Iran
Bombay and Para-Bombay phenotypes are characterized by FUT1 gene mutation and lack of H antigen expression in red blood cells. ABH antigens are not present in the body secretions of Bombay individuals, while they are expressed in the secretions of para-Bombay. The aim of this study was to investigate the molecular basis of FUT1 and FUT2 genes in Iranians with the Bombay or Para-Bombay phenotype. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - January 5, 2023 Category: Hematology Authors: Faeze Shahriyari, Arezoo Oodi, Fatemeh Nasiri Kenari, Majid Shahabi Source Type: research
Cold Stored Platelets – Increasing Understanding and Acceptance
Platelet transfusions decreased the risk of morbidity and mortality secondary to thrombocytopenia. This therapy not only ameliorates platelet loss in bleeding patients,but also those with acquired dysfunction of platelets. The current standard of practice worldwide is to provide room temperature platelets (RTPs); however, there are many disadvantages to the use of RTPs such that alternative approaches have been explored. One potential approach is the integration and use of cold stored platelets (CSP), which are platelets stored at 1 to 6 °C, in clinical settings. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - January 4, 2023 Category: Hematology Authors: Richard R. Gammon, Jeffrey Hebert, Kyungyoon Min, John J O ’Connor, Tina Ipe, Anna Razatos, Stefan Reichenberg, James Stubbs, Elizabeth Waltman, Yanyun Wu Source Type: research
Preserved SARS-CoV-2 neutralizing IgG activity of in-house manufactured COVID-19 convalescent plasma
In the current study, we aimed to evaluate the neutralizing IgG activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as the coagulation factors of convalescent plasmas which we manufactured in-house without a fast-freezing technique. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - December 28, 2022 Category: Hematology Authors: Makoto Inada, Tomiteru Togano, Mari Terada, Katsuyuki Shiratori, Shinya Tsuzuki, Yuki Takamatsu, Sho Saito, Akira Hangaishi, Shinichiro Morioka, Satoshi Kutsuna, Kenji Maeda, Hiroaki Mitsuya, Norio Ohmagari Source Type: research
Evidence for Adverse Effects by G-CSF in Some Acute Lymphoblastic Leukemias
Dear Editor, (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - December 19, 2022 Category: Hematology Authors: Justin Kelley, Laura Cooling Tags: Letter to the Editor Source Type: research
Prevalence of hemorrhagic ovarian cysts in patients with rare inherited bleeding disorders
In this study, we sought to determine the prevalence of HOCs in a large cohort of Iranian patients with RBDs. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - December 17, 2022 Category: Hematology Authors: Omid Seidizadeh, Ghasem Miri Aliabad, Ilia Mirzaei, Saeedeh Yaghoubi, Sima Abtin, Amir Valikhani, Majid Naderi Source Type: research
Autoimmune complications of COVID-19 and potential consequences for long-lasting disease syndromes
The latest WHO report determined the increasing diversity within the CoV-2 omicron and its descendent lineages. Some heavily mutated offshoots of BA.5 and BA.2, such as BA.4.6, BF.7, BQ.1.1, and BA.2.75, are responsible for about 20% of infections and are spreading rapidly in multiple countries. It is a sign that Omicron subvariants are now developing a capacity to be more immune escaping and may contribute to a new wave of COVID-19. Covid-19 infections often induce many alterations in human physiological defense and the natural control systems, with exacerbated activation of the inflammatory and homeostatic response, as f...
Source: Transfusion and Apheresis Science - December 16, 2022 Category: Hematology Authors: Jean AMIRAL, Jerard Seghatchian Source Type: research
The ISBT e-learning module in transfusion reaction: An initiative for a global outreach
Physician ’s knowledge of transfusion medicine (TM) is critical for patient’s safety. Blood transfusion is not without risks with ongoing concerns on both infectious and non-infectious complications. Practice interventions are essential in order to ensure safety of the transfusion cycle. The use of e-lear ning methodologies (such as computer software, smartphone applications, or website resource) has already become an integral part of medical education [1]. E-learning provides a self-paced platform that offers adaption to the recipient’s learning objectives and speed of acquiring knowledge [2]. (Source: Transfusion a...
Source: Transfusion and Apheresis Science - December 15, 2022 Category: Hematology Authors: Tomasz Wasiluk, Cynthia So- Osman, Peter van den Burg, Eszter Herczenik, Arwa Z. Al-Riyami Source Type: research
Modernizing transfusion medicine education
Blood transfusion is one of the most common medical procedures [1]. Even though blood transfusion could be life-saving in some circumstances, it also carries significant risks [2]. Inappropriate utilization of blood transfusion is well documented [3] and may stem from poor transfusion knowledge amongst medical professionals. Numerous studies have shown that medical trainees receive limited education in transfusion; furthermore, its content is not always relevant. Not surprisingly, medical trainees score poorly on knowledge assessments in transfusion. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - December 15, 2022 Category: Hematology Authors: K. Pavenski Source Type: research
The ISBT E-learning module in transfusion reaction; An initiative for a global outreach
Physician ’s knowledge of transfusion medicine (TM) is critical for patient’s safety. Blood transfusion is not without risks with ongoing concerns on both infectious and non-infectious complications. Practice interventions are essential in order to ensure safety of the transfusion cycle. The use of e-lear ning methodologies (such as computer software, smartphone applications, or website resource) has already become an integral part of medical education [1]. E-learning provides a self-paced platform that offers adaption to the recipient’s learning objectives and speed of acquiring knowledge [2]. (Source: Transfusion a...
Source: Transfusion and Apheresis Science - December 15, 2022 Category: Hematology Authors: Tomasz Wasiluk, Cynthia So- Osman, van den Burg Peter, Eszter Herczenik, Arwa Z. Al-Riyami Source Type: research
Spotlight on SARS CoV-2 infection inducing autoimmunity, through the formation of autoantibody to self hemostatic components or to host cells, often leading to severe thrombotic or bleeding events
WHAT ’S ’HAPPNING? [TRASCI 62.1 NOV ISSUE] (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - December 14, 2022 Category: Hematology Authors: Jerard Seghatchian Source Type: research
