Thawed plasma (TP) as a Substitute for Intravenous Immune globulin (IVIG) to Prevent Hypogammaglobulinemia Post-Therapeutic Plasma Exchange
Intravenous immune globulin (IVIG) is a common treatment given after plasma exchange procedures to either prevent secondary hypogammaglobulinemia or as an adjunctive treatment for organ transplant rejection. However, side-effects are relatively common with this medication during and after infusion. This case-report describes our alternative to IVIG infusions post-plasma exchange. We hypothesize that in patients unable to tolerate IVIG, using thawed plasma as a replacement fluid provides a suitable increase in the patients post procedure immunoglobulin G (IgG) levels for patients with secondary hypogammaglobulinemia that ar...
Source: Transfusion and Apheresis Science - May 2, 2023 Category: Hematology Authors: Lance A. Williams, Brittney A. Thiele, Theresa Kinard, Erin Kaleta, Jill Adamski, Leon Su, Shauna Jones, Qun Lu Source Type: research
The implementation of Automated Red Blood Cell Exchange (Erythrocytapheresis) as a Treatment Modality in Sickle Cell Disease Patients: Single Center Experience
Improvements of health infrastructure, preventive care and clinical management is important to reduce the morbidity and mortality of sickle cell disease (SCD). (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 2, 2023 Category: Hematology Authors: Fatma Soliman Elsayed Ebeid Source Type: research
A rare complication of leukostasis with AML M4 patient: Microcirculatory dysfunction of upper extremities
In children with acute myeloid leukemia, the incidence of hyperleukocytosis is 5 –33%. Patients with AML and hyperleukocytosis have a higher early mortality rate than patients with nonhyperleukocytic AML because of the increased risk of severe pulmonary and neurologic complications. Leukapheresis provides rapid cytoreduction and reduces early mortality rates. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 1, 2023 Category: Hematology Authors: İrem Ersayoğlu, Pınar Yazıcı Özkaya, Hamdi Metin, Hamiyet Hekimci, Kazım Zararcı, Deniz Yılmaz Karapınar, Bülent Karapınar Source Type: research
A Rare Complication of Leukostasis With AML M4 Patient: Microcirculatory. Dysfunction of Upper Extremities
In children with acute myeloid leukemia, the incidence of hyperleukocytosis is 5- 33%. Patients with AML and hyperleukocytosis have a higher early mortality rate than patients with nonhyperleukocytic AML because of the increased risk of severe pulmonary and neurologic complications. Leukapheresis provides rapid cytoreduction and reduces early mortality rates. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - May 1, 2023 Category: Hematology Authors: İrem ERSAYOĞLU, Pınar YAZICI ÖZKAYA, Hamdi METİN, Hamiyet HEKİMCİ, Kazım ZARARCI, Deniz YILMAZ KARAPINAR, Bülent KARAPINAR Source Type: research
Convalescent plasma regulation: a message in a bottle to the societies and regulatory authorities outside the us.
Dear Editor, (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 26, 2023 Category: Hematology Authors: Daniele Focosi, Massimo Franchini Source Type: research
Comparison of Severity and Prognosis of Jaundice due to Rh Incompatibility and G6PD Deficiency
This study was designed to define the severity and prognosis in jaundiced infants with Rh incompatibility or G6PD deficiency. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 25, 2023 Category: Hematology Authors: Hassan Boskabadi, Ali Moradi, Maryam Zakerihamidi Source Type: research
Use of n-acetylcysteine therapy in patients with relapsed refractory thrombotic thrombocytopenic purpura
There is limited data on the use of NAC in the literature. We would like to present the satisfactory results we obtained in our resistant and relapsed patients as a case series.Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy caused by ADAMTS13 (a disintegrin with thrombospondin type 1 motif and metalloprotease activity, member13) deficiency. Von Willebrand factor (vWF) initiates platelet aggregation and thus thrombus formation. The multimers of vWF are cleaved by ADAMTS13. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 21, 2023 Category: Hematology Authors: Ozlem Beyler, Cengiz Demir Source Type: research
A Case of Hyperhemolysis Syndrome in Sickle Cell Disease and Concomitant COVID-19
Hyperhemolysis syndrome (HHS) is an uncommon transfusion reaction described in several hematologic disorders, including sickle cell disease (SCD). HHS is characterized by a decline in hemoglobin (Hb) values below pre-transfusion levels following transfusion of red blood cells (RBCs), coupled with laboratory markers consistent with hemolysis. The proposed pathophysiologic mechanisms underlying HHS include increased phosphatidylserine expression, macrophage activation, and complement dysregulation. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 13, 2023 Category: Hematology Authors: Allen Green, Heather Jones, Alecia Nero, Ibrahim F. Ibrahim, Ravi Sarode, Lisa M. Scheid, Christopher B. Webb, Brian D. Adkins, Sean G. Yates Source Type: research
Optimizing of the isolation of hematopoietic stem cell in bone marrow transplantation in children
Most of collected hematopoietic stem cell (HSCs) products need processing in order to isolate stem cells, squeeze out of plasma and erythrocytes. There are two main aims for bone marrow (BM) enrichment: reduction of immunogenicity of AB0 incompatible transplants and/or preventing toxicity of hemolysis during cryopreservation. In our center we have implemented two methods for BM enrichment: manual technic using 10% HAES (hydroxyethyl starch) and automatic cell separator. In order to optimize the process, we examined retrospectively the parameters which could have a great impact on final efficiency of engraftment, such as re...
Source: Transfusion and Apheresis Science - April 12, 2023 Category: Hematology Authors: Monika Sawa, Magdalena Zatorska-Kwieci ńska, Jolanta Goździk Source Type: research
Extended platelet transfusion in bleeding patients with platelet transfusion refractoriness
Platelet transfusion refractoriness (PTR), defined as the failure to increase platelet number after transfusion [1], is a common finding among patients with haematological conditions undergoing chemotherapy [2], who consequently may develop life-threatening bleeding complications. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 11, 2023 Category: Hematology Authors: Tatiana Fern ández-Barge, Juan J. Domínguez-García, Alba Díaz-Santander, Raquel Rivero-Fernández, Rodrigo Cantera-Estefanía, Gala A. Mendez, Íñigo Romón Source Type: research
Hereditary Thrombocytopenia with Familial Novel Mutation in MYH9 Gene: A Familial Case Report
One of the rarest types of hereditary thrombocytopenia is the MYH9-related disorder. This spectrum of disorders is characterized by large platelets with or without leukocyte inclusion bodies, a decrease in the total number of platelets, and autosomal dominant inheritance. Proteinuric nephropathy that frequently progresses to end-stage renal failure, as well as the beginning of progressive high-frequency sensorineural hearing loss in young adults, is also associated with MYH9-related disorder. In this case report, we presented three family members who had thrombocytopenia and in whom a heterozygous novel 22bp deletion (c.42...
Source: Transfusion and Apheresis Science - April 5, 2023 Category: Hematology Authors: Rafiye Ciftciler, Özgur Balasar, Hilal Keyik, Ali Erdinc Ciftciler Source Type: research
Equilibration Time of Haemoglobin Concentration after Packed Red Blood Cell Transfusion in Children seen in the Emergency Unit of a Tertiary Hospital in Southeast, Nigeria
This study was therefore aimed at determining the appropriate time to assess Hb concentration after packed red blood cell (pRBC) transfusion in children using 5 different time intervals. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 4, 2023 Category: Hematology Authors: Victor Eze Enya, Maria-Lauretta Chito Orji, Biobele J. Brown Source Type: research
Editorial Board
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - March 28, 2023 Category: Hematology Source Type: research
Impact of Covid 19 pandemic on hematopoietic stem cell transplantation activities: report from a single center
The current COVID-19 pandemic has placed unprecedented stress on the healthcare system, including HSCT. Several international organizations have created guidelines for managing different aspects of HSCT in the context of the pandemic.Comparing 2019 and 2020, our transplant center performed the same number of transplants. In both periods, transplants were mainly for patients with acute leukemia; thus, the urgency criteria was respected in light of pandemic restraints. Transplants by sibling donors and cord blood units remained the same, while transplants by unrelated donors were increased, in particular from European regist...
Source: Transfusion and Apheresis Science - March 28, 2023 Category: Hematology Authors: Sabrina Giammarco, Simona Sica, Elisabetta Metafuni, Maria Assunta Limongiello, Caterina Giovanna Valentini, Federica Sor à, John Donald Marra, Andrea Bacigalupo, Luciana Teofili, Patrizia Chiusolo Source Type: research
Real-world clinical characterization, healthcare resource utilization and productivity loss in chronic graft versus host patients exposed to extracorporeal photopheresis in Sweden
Extracorporeal photopheresis (ECP) is frequently used to treat moderate-severe chronic graft versus host disease (cGVHD), however limited data exists describing ECP treatment effects on healthcare and societal costs. We aimed to characterize clinical and health economic outcomes and productivity loss in cGVHD patients exposed to ECP. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - March 20, 2023 Category: Hematology Authors: Frida Schain, Constance Boissin, Tamas Laczik, Stefano Fedeli, Mats Remberger, Ola Blennow, Josefina Dykes, Torsten Eich, Christina Jones, Jonas Mattsson, G östa Berlin Source Type: research
