Thyroid Dysfunction Risk After Iodinated Contrast Media Administration: A Prospective Longitudinal Cohort Analysis
CONCLUSIONS: There is a rare long-term risk of an excess iodine load on thyroid dysfunction even among individuals from an overall iodine-sufficient region, supporting the need for targeted monitoring following iodinated contrast administration.PMID:38700099 | DOI:10.1210/clinem/dgae304 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 3, 2024 Category: Endocrinology Authors: Seo Young Sohn Kosuke Inoue Muhammad T Bashir Jesse W Currier Natalia V Neverova Ramin Ebrahimi Connie M Rhee Martin L Lee Angela M Leung Source Type: research

The influence of trinucleotide repeats in the androgen receptor gene on androgen-related traits and diseases
CONCLUSION: In this large-scale study, we found that longer CAG and GGC repeats in the AR gene influence androgen resistance, elevate circulating testosterone level via a feedback loop and play a role in some androgen-targeted tissues. Generally, however, circulating testosterone level is a more important determinant of androgen action in males than repeat lengths.PMID:38701087 | DOI:10.1210/clinem/dgae302 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 3, 2024 Category: Endocrinology Authors: Takayoshi Sasako Yann Ilboudo Kevin Y H Liang Yiheng Chen Satoshi Yoshiji J Brent Richards Source Type: research

Can incorporating molecular testing improve the accuracy of newborn screening for congenital adrenal hyperplasia?
CONCLUSIONS: Incorporation of molecular testing could improve the accuracy of CAH NBS, although some distinct challenges of molecular testing may need to be considered before implementation by NBS programs.PMID:38701341 | DOI:10.1210/clinem/dgae297 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 3, 2024 Category: Endocrinology Authors: Kyriakie Sarafoglou Amy Gaviglio Carrie Wolf Cindy P Lorentz Aida Lteif Jennifer Kyllo Gretchen Radloff Zachary Detwiler Carla D Cuthbert James S Hodges Scott D Grosse Christopher N Greene Suzanne Cordovado Source Type: research

Metabolic Syndrome and the Risk of Kidney Stones: a Large-scale Cohort Study from 487,860 UK Biobank participants
CONCLUSION: Metabolic syndrome is a significant and independent risk factor for the development of kidney stones. This association suggests that kidney stones may represent a systemic disorder influenced by the interplay of various metabolic risk factors.PMID:38701346 | DOI:10.1210/clinem/dgae295 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 3, 2024 Category: Endocrinology Authors: Minghui Liu Meng Gao Jian Wu Zewu Zhu Jiao Hu Hequn Chen Zhiyong Chen Jinbo Chen Source Type: research

Cost-effectiveness of genetic testing of endocrine tumor patients using a comprehensive hereditary cancer gene panel
DISCUSSION: Using comprehensive multigene panel results in faster turnaround time and cost-efficiently identifies genetic alterations in hereditary endocrine tumor syndromes. Incidentally identified variants in patients with poor prognoses may serve as a potential therapeutic target in tumors where therapeutic possibilities are limited.PMID:38701358 | DOI:10.1210/clinem/dgae300 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 3, 2024 Category: Endocrinology Authors: Attila Pat ócs Petra Nagy J ános Papp Anik ó Bozsik B álint Antal Vince Korn él Grolmusz T ímea Pócza Henriett Butz Source Type: research

Risk Assessment of Diabetes Mellitus during and after Pregnancy in Women with Prolactinomas
CONCLUSIONS: Low PRL levels before pregnancy may be detrimental to FG during pregnancy. CAB duration and dose may influence long-term glucose tolerance, besides family history and BMI. Pre-conceptional metabolic management should be recommended to reduce the risk of gestational and type 2 diabetes mellitus.PMID:38693775 | DOI:10.1210/clinem/dgae289 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Roberta Scairati Renata S Auriemma Sara Di Meglio Guendalina Del Vecchio Rosa Pirchio Chiara Graziadio Claudia Pivonello Rosario Pivonello Annamaria Colao Source Type: research

Improvement of β-Cell Function After Switching From DPP-4 Inhibitors to Oral Semaglutide: SWITCH-SEMA2 Post Hoc Analysis
CONCLUSION: Switching to oral semaglutide ameliorated β-cell function compared with DPP-4is, presumably via tissue-to-tissue crosstalk between liver and β-cells.PMID:38695547 | DOI:10.1210/clinem/dgae213 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Hiroshi Nomoto Sho Furusawa Hiroki Yokoyama Yuka Suzuki Rimi Izumihara Yuki Oe Kiyohiko Takahashi Aika Miya Hiraku Kameda Kyu Yong Cho Jun Takeuchi Yoshio Kurihara Akinobu Nakamura Tatsuya Atsumi Source Type: research

Risk Assessment of Diabetes Mellitus during and after Pregnancy in Women with Prolactinomas
CONCLUSIONS: Low PRL levels before pregnancy may be detrimental to FG during pregnancy. CAB duration and dose may influence long-term glucose tolerance, besides family history and BMI. Pre-conceptional metabolic management should be recommended to reduce the risk of gestational and type 2 diabetes mellitus.PMID:38693775 | DOI:10.1210/clinem/dgae289 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Roberta Scairati Renata S Auriemma Sara Di Meglio Guendalina Del Vecchio Rosa Pirchio Chiara Graziadio Claudia Pivonello Rosario Pivonello Annamaria Colao Source Type: research

Improvement of β-Cell Function After Switching From DPP-4 Inhibitors to Oral Semaglutide: SWITCH-SEMA2 Post Hoc Analysis
CONCLUSION: Switching to oral semaglutide ameliorated β-cell function compared with DPP-4is, presumably via tissue-to-tissue crosstalk between liver and β-cells.PMID:38695547 | DOI:10.1210/clinem/dgae213 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Hiroshi Nomoto Sho Furusawa Hiroki Yokoyama Yuka Suzuki Rimi Izumihara Yuki Oe Kiyohiko Takahashi Aika Miya Hiraku Kameda Kyu Yong Cho Jun Takeuchi Yoshio Kurihara Akinobu Nakamura Tatsuya Atsumi Source Type: research

Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA)
CONCLUSIONS: 1) Between-method Tg variability necessitates method continuity when monitoring the Tg trends of TgAb- DTC patients. 2) The presence and concentration of TgAb appeared to have a lowering effect on serum Tg measured by all methodologies (IMA, MS and RIA). 3) Since the reliability of Tg measured in the presence of TgAb is often uncertain, the TgAb trend (measured by the same method) may be a useful surrogate DTC tumor marker.PMID:38686504 | DOI:10.1210/clinem/dgae286 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ivana Petrovic Jonathan LoPresti Shireen Fatemi Andrew Gianoukakis Kenneth Burman Cristiane J Gomez-Lima Caroline T Nguyen Carole Ann Spencer Source Type: research

Basal Hyperglycemia Contributes More Than Fifty Percent to Time in Range in Pregnant Women with Type 1 Diabetes
CONCLUSIONS: Basal hyperglycemia was the major contributor to TIR during pregnancy. Along with controlling the postprandial hyperglycemia, pregnant women with T1DM who did not reach the target of TIR may benefit more from the optimization of insulin regimens focusing on reducing basal glucose.PMID:38686666 | DOI:10.1210/clinem/dgae291 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ping Ling Daizhi Yang Chaofan Wang Xueying Zheng Sihui Luo Xubin Yang Hongrong Deng Wen Xu Jinhua Yan Jianping Weng Source Type: research

The association of cardiometabolic, diet and lifestyle parameters with plasma glucagon-like peptide-1: An IMI DIRECT study
CONCLUSION: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.PMID:38686701 | DOI:10.1210/clinem/dgae119 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Rebeca Eriksen Margaret C White Adem Y Dawed Isabel Garcia Perez Joram M Posma Mark Haid Sapna Sharma Cornelia Prehn Louise E Thomas Robert W Koivula Roberto Bizzotto Andrea Mari Giuseppe N Giordano Imre Pavo Jochen M Schwenk Federico De Masi Konstantinos Source Type: research

Associations Between Beverage Consumption and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes
CONCLUSION: Higher consumption of ASBs and SSBs was linearly associated with an increased risk of microvascular complications in adults with T2D.PMID:38687598 | DOI:10.1210/clinem/dgae242 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Xiaoyu Lin Kai Zhu Zixin Qiu Rui Li Lin Li Qi Lu Ruyi Li Hancheng Yu Sen Liu Tianyu Guo Kun Yang Yunfei Liao An Pan Gang Liu Source Type: research

Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA)
CONCLUSIONS: 1) Between-method Tg variability necessitates method continuity when monitoring the Tg trends of TgAb- DTC patients. 2) The presence and concentration of TgAb appeared to have a lowering effect on serum Tg measured by all methodologies (IMA, MS and RIA). 3) Since the reliability of Tg measured in the presence of TgAb is often uncertain, the TgAb trend (measured by the same method) may be a useful surrogate DTC tumor marker.PMID:38686504 | DOI:10.1210/clinem/dgae286 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ivana Petrovic Jonathan LoPresti Shireen Fatemi Andrew Gianoukakis Kenneth Burman Cristiane J Gomez-Lima Caroline T Nguyen Carole Ann Spencer Source Type: research

Basal Hyperglycemia Contributes More Than Fifty Percent to Time in Range in Pregnant Women with Type 1 Diabetes
CONCLUSIONS: Basal hyperglycemia was the major contributor to TIR during pregnancy. Along with controlling the postprandial hyperglycemia, pregnant women with T1DM who did not reach the target of TIR may benefit more from the optimization of insulin regimens focusing on reducing basal glucose.PMID:38686666 | DOI:10.1210/clinem/dgae291 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ping Ling Daizhi Yang Chaofan Wang Xueying Zheng Sihui Luo Xubin Yang Hongrong Deng Wen Xu Jinhua Yan Jianping Weng Source Type: research