Zollinger-Ellison Syndrome Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics
Pharmacol Rep. 2023 May 4. doi: 10.1007/s43440-023-00489-x. Online ahead of print.ABSTRACTProton pump inhibitors (PPIs) are the most commonly prescribed drugs for the treatment of non-erosive reflux disease (NERD), ulcers associated with non-steroidal anti-inflammatory drugs (NSAIDs), esophagitis, peptic ulcer disease (PUD), Zollinger-Ellison syndrome (ZES), gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and Helicobacter pylori eradication therapy. The drugs have the effect of inhibiting acid production in the stomach. According to research, PPIs can affect the composition of gut microbiota and modulate the i...
Source: Pharmacological Reports - May 4, 2023 Category: Drugs & Pharmacology Authors: Aneta Kiecka Marian Szczepanik Source Type: research

Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics
Pharmacol Rep. 2023 May 4:1-14. doi: 10.1007/s43440-023-00489-x. Online ahead of print.ABSTRACTProton pump inhibitors (PPIs) are the most commonly prescribed drugs for the treatment of non-erosive reflux disease (NERD), ulcers associated with non-steroidal anti-inflammatory drugs (NSAIDs), esophagitis, peptic ulcer disease (PUD), Zollinger-Ellison syndrome (ZES), gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and Helicobacter pylori eradication therapy. The drugs have the effect of inhibiting acid production in the stomach. According to research, PPIs can affect the composition of gut microbiota and modulate ...
Source: Pharmacological Reports - May 4, 2023 Category: Drugs & Pharmacology Authors: Aneta Kiecka Marian Szczepanik Source Type: research

Sporadic and MEN1-related gastrinoma and Zollinger –Ellison syndrome: differences in clinical characteristics and survival outcomes
ConclusionMEN-1/ZES patients generally show better OS and PFS than Sp-ZES as well as better SSAs response. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 28, 2023 Category: Endocrinology Source Type: research

Insulinoma and subsequent Zollinger-Ellison syndrome as an expression of phenotype exchange in a pancreatic neuroendocrine tumor
Med Clin (Barc). 2023 Mar 31:S0025-7753(23)00113-6. doi: 10.1016/j.medcli.2023.03.004. Online ahead of print.NO ABSTRACTPMID:37005122 | DOI:10.1016/j.medcli.2023.03.004 (Source: Medicina Clinica)
Source: Medicina Clinica - April 2, 2023 Category: General Medicine Authors: Fernando Guerrero-P érez Inmaculada Peir ó Carles Villabona Source Type: research

Cancers, Vol. 15, Pages 1377: Successful Lifetime/Long-Term Medical Treatment of Acid Hypersecretion in Zollinger-Ellison Syndrome (ZES): Myth or Fact? Insights from an Analysis of Results of NIH Long-Term Prospective Studies of ZES
This study includes the results from all 303 patients with established ZES who were prospectively followed and received acid antisecretory treatment with either H2Rs or PPIs, with antisecretory doses individually titrated by the results of regular gastric acid testing. The study includes patients treated for short-term periods (&lt;5 yrs), patients treated long-term (&gt;5 yrs), and patients with lifetime treatment (30%) followed for up to 48 years (mean 14 yrs). Long-term/lifelong acid antisecretory treatment with H2Rs/PPIs can be successfully carried out in all patients with both uncomplicated and complic...
Source: Cancers - February 21, 2023 Category: Cancer & Oncology Authors: Tetsuhide Ito Irene Ramos-Alvarez Robert T. Jensen Tags: Article Source Type: research

How to treat gastrinomas in patients with multiple endocrine neoplasia type1: surgery or long-term proton pump inhibitors?
AbstractIn patients with multiple endocrine neoplasia type 1 syndrome (MEN 1) and Zollinger –Ellison syndrome (ZES), gastrinomas arise from the duodenum, about 60% are multiple, and about 15% of patients have coexisting pancreatic gastrinomas, which can be localized by the selective arterial secretagogue injection test (SASI test). The guidelines (GLs) by the Japanese Neuroendocrine Tumo r Society (JNETS) recommend surgical resection for functioning duodenopancreatic neuroendocrine tumors (NETs), including gastrinomas, in patients with MEN1 (Grade A, 100% agreement among members). Conversely, the GLs of the National Comp...
Source: Surgery Today - December 7, 2022 Category: Surgery Source Type: research

The Zollinger –Ellison Syndrome
New England Journal of Medicine,Volume 387, Issue 18, Page 1699-1699, November 2022. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 2, 2022 Category: Internal Medicine Authors: Quentin Binet Ivan Borbath Source Type: research

Neurofibromatosis Type 1: A Rare Predisposition for Gastrinomas and Other Neuroendocrine Tumors
We present the case of a 52-year-old lady who presented with recurrent peptic ulceration and diarrhea. Serum gastrin levels were elevated and magnetic resonance imaging demonstrated the presence of a pancreatic lesion with multiple liver metastases. The lesion was moderately fludeoxyglucose avid on positron emission tomography-computed tomography. Endoscopic ultrasonography-guided sampling revealed the presence of synaptophysin positive neuroendocrine cells with positive gastrin immunostaining. A conservative approach was adopted, and the patient's symptoms improved on proton pump inhibitors. Zollinger-Ellison syndrome is ...
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Case Report Source Type: research

Gastric neuroendocrine neoplasms: a primer for radiologists
AbstractGastric neuroendocrine neoplasms are uncommon tumors with variable differentiation and malignant potential. Three main subtypes are recognized: type 1, related to autoimmune atrophic gastritis; type 2, associated with Zollinger –Ellison and MEN1 syndrome; and type 3, sporadic. Although endoscopy alone is often sufficient for diagnosis and management of small, indolent, multifocal type 1 tumors, imaging is essential for evaluation of larger, high-grade, and type 2 and 3 neoplasms. Hypervascular intraluminal gastric masses are typically seen on CT/MRI, with associated perigastric lymphadenopathy and liver metastase...
Source: Abdominal Imaging - April 12, 2022 Category: Radiology Source Type: research

Cancers, Vol. 14, Pages 1928: Pancreaticoduodenectomy Is the Best Surgical Procedure for Zollinger & ndash;Ellison Syndrome Associated with Multiple Endocrine Neoplasia Type 1
Conclusions: Initial PD seems to be the superior surgical procedure for MEN1-ZES, resulting in a long-term cure rate of about 80%, fewer duodenopancreatic reoperations, and an acceptable quality of life. (Source: Cancers)
Source: Cancers - April 11, 2022 Category: Cancer & Oncology Authors: Weihua Kong Max Benjamin Albers Jerena Manoharan Joachim Nils Goebel Peter Herbert Kann Moritz Jesinghaus Detlef Klaus Bartsch Tags: Article Source Type: research