Zollinger-Ellison Syndrome Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The cckOMA syndrome and its relation to the Zollinger-Ellison syndrome: a diagnostic challenge
CONCLUSION: Obviously, the clinical awareness about the CCKoma syndrome is limited. Moreover, it is also likely that the knowledge about the necessary specificity demands of diagnostic gastrin and CCK assays have obscured proper diagnosis of the CCKoma syndromes in man.PMID:38299632 | DOI:10.1080/00365521.2024.2308532 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - February 1, 2024 Category: Gastroenterology Authors: Jens F Rehfeld Source Type: research

PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes
In this study, we aimed to establish the physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics of pantoprazole in populations with various CYP2C19 metabolic activities. A comprehensive investigation of previous reports and drug databases was conducted to collect the clinical pharmacogenomic data, physicochemical data, and disposition properties of pantoprazole, and the collected data were used for model establishment. The model was evaluated by comparing the predicted plasma concentration-time profiles and/or pharmacokinetic parameters (AUC and Cmax) with the clinical observation results. The p...
Source: Archives of Pharmacal Research - December 27, 2023 Category: Drugs & Pharmacology Authors: Chang-Keun Cho Eunvin Ko Ju Yeon Mo Pureum Kang Choon-Gon Jang Seok-Yong Lee Yun Jeong Lee Jung-Woo Bae Chang-Ik Choi Source Type: research

Management of Gastric Neuroendocrine Tumors: A Review
Ann Surg Oncol. 2023 Dec 7. doi: 10.1245/s10434-023-14712-9. Online ahead of print.ABSTRACTGastric neuroendocrine tumors (G-NET) are rare tumors arising from enterochromaffin-like cells of the gastric mucosa. They belong to a larger group called gastroenteropancreatic neuroendocrine tumors and are classified as low, intermediate, or high-grade tumors based on their proliferative indices. They are further categorized into three subtypes based on their morphologic characteristics, pathogenesis, and behavior. Types 1 and 2 tumors are characterized by elevated serum gastrin and are usually multifocal. They typically occur in t...
Source: Ann Oncol - December 7, 2023 Category: Cancer & Oncology Authors: Caitlin Sok Pranay S Ajay Vasileios Tsagkalidis David A Kooby Mihir M Shah Source Type: research

Multiple endocrine neoplasia type 1 with Zollinger –Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry
ConclusionPancreaticoduodenectomy is the most effective treatment for ZES. Long-term follow-up is essential for pulmonary NET G2 owing to the risk of distant metastasis and/or multiplicity. Moreover, the variability of menin IHC in MEN1-related tumors may indicate the pattern of tumor formation rather than the diagnostic utility of menin in MEN1. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - October 6, 2023 Category: Endocrinology Source Type: research

ACTH-secreting pancreatic neuroendocrine neoplasms: A case-series
J Neuroendocrinol. 2023 Aug 19:e13336. doi: 10.1111/jne.13336. Online ahead of print.ABSTRACTEctopic Cushing's syndrome (CS) occurs rarely in patients with pancreatic neuroendocrine neoplasms. Early recognition of symptoms is critical given the high morbidity and mortality associated with CS. A database of pancreatic neuroendocrine neoplasms (NENs) seen at the Moffitt Cancer Center between 1/2008 and 4/2022 was reviewed and cases of ectopic CS were identified. Information was extracted on tumor characteristics, clinical signs and symptoms, therapies, and outcomes. Thirteen cases were identified, ranging in age from 16 to 6...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Taymeyah Al-Toubah Eleonora Pelle Julie Hallanger-Johnson Mintallah Haider Jonathan Strosberg Source Type: research

Over 30 Years of Omeprazole
CONCLUSION: Omeprazole is the prototypical drug in the management of APDs and has withstood the test of time. After 3 decades, omeprazole remains the drug of choice in managing APD.PMID:37651247 | DOI:10.59556/japi.71.0322 (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - August 31, 2023 Category: General Medicine Authors: Praveen Sharma Source Type: research