Manifestation of Zollinger-Ellison-Syndrome with hypovolemic shock
A 63-year-old male patient presented to a secondary hospital suffering from severe epigastric pain, vomiting and mild diarrhea for the last few hours. Since many months he experienced increasing fatigue and loss of appetite. Furthermore, recurring mild epigastric pain persisted since many years. A gastroscopy in the ambulatory setting has been unremarkable. These gastrointestinal symptoms had improved under proton-pump-inhibitor (PPI) therapy but recurred after discontinuation. Medical history revealed a diagnosis of arterial hypertension treated with lisinopril 20mg and hydrochlorothiazide 25mg, each once daily. (Source: ...
Source: The American Journal of Medicine - February 19, 2020 Category: General Medicine Authors: Alexander C. Reisinger, Philipp Eller, Gernot Schilcher, Florian Eisner, Philipp Kreuzer, Gerald Hackl, Walter Spindelb öck, Johannes Plank, Patrizia Kump Tags: Diagnostic Dilemma Source Type: research

Manifestation of Zollinger-Ellison Syndrome With Hypovolemic Shock
A 63-year-old male patient presented to a secondary hospital suffering from severe epigastric pain, vomiting, and mild diarrhea for the last few hours. He said that he had experienced increasing fatigue and loss of appetite for many months prior. Furthermore, recurring mild epigastric pain persisted for many years. A gastroscopy in the ambulatory setting was unremarkable. These gastrointestinal symptoms had improved with proton pump inhibitor (PPI) therapy but recurred after discontinuation. Medical history revealed a diagnosis of arterial hypertension treated with lisinopril 20 mg and hydrochlorothiazide 25 mg, each once ...
Source: The American Journal of Medicine - February 19, 2020 Category: General Medicine Authors: Alexander C. Reisinger, Philipp Eller, Gernot Schilcher, Florian Eisner, Philipp Kreuzer, Gerald Hackl, Walter Spindelb öck, Johannes Plank, Patrizia Kump Tags: Diagnostic Dilemma Source Type: research

Jejunal Perforations in Zollinger-Ellison Syndrome: Expect the Unexpected.
PMID: 32106911 [PubMed - in process] (Source: The American Surgeon)
Source: The American Surgeon - February 1, 2020 Category: Surgery Authors: Freund MR, Reissman P, Schwarz AD Tags: Am Surg Source Type: research

Atypical Thymic Carcinoid in a Patient with Zollinger-Ellison Syndrome.
In this report, we share our experience treating atypical thymic carcinoid in a patient with Zollinger-Ellison syndrome. PMID: 31832379 [PubMed] (Source: Korean Journal of Thoracic and Cardiovascular Surgery)
Source: Korean Journal of Thoracic and Cardiovascular Surgery - December 15, 2019 Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research

Zollinger-Ellison syndrome.
Authors: Zimmer V, Glanemann M, Lammert F PMID: 31818929 [PubMed - in process] (Source: Canadian Medical Association Journal)
Source: Canadian Medical Association Journal - December 11, 2019 Category: General Medicine Tags: CMAJ Source Type: research

Diagnostic accuracy of selective arterial calcium injection test for localization of gastrinoma.
In conclusion, our data suggest the strongest gastrin response evoked by SACI indicates the definitive location in patients with gastrinomas. In contrast, SACI could not accurately locate multiple gastrin-secreting lesions due to poor specificity. PMID: 31813923 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - December 10, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Roar Str øm - the Norwegian surgeon who was three years ahead of Zollinger and Ellison.
This article aims to highlight his professional achievements. MATERIAL AND METHOD: We searched archives and reference databases for information on Roar Strøm. RESULTS: Roar Strøm grew up in Oslo, where he graduated with a medical degree in 1926, at just 23 years of age. Strøm pursued a focused career in surgery: specialist in surgery in 1935, medical doctorate in 1942, and senior consultant in surgery at Rogaland Hospital in Stavanger over the period 1945-1956. While in Stavanger, he published the extensive case history in Acta Chirurgica Scandinavica. The patient had a multi-year medical his...
Source: Tidsskrift for den Norske Laegeforening - December 10, 2019 Category: General Medicine Authors: Søreide JA, Hem E Tags: Tidsskr Nor Laegeforen Source Type: research

Case report: optimal tumor cytoreduction and octreotide with durable disease control in a patient with MEN-1 and Zollinger-Ellison syndrome —over a decade of follow-up
Zollinger-Ellison syndrome (ZES) is a rare condition characterized by hypersecretion of gastrin by gastrinoma tumors leading to severe peptic ulcer disease with potential development of gastric carcinoid tumor... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - December 9, 2019 Category: Cancer & Oncology Authors: Lynsey M. Daniels, Marian Khalili, William F. Morano, Michaela Simoncini, Beth C. Mapow, Andrea Leaf and Wilbur B. Bowne Tags: Case report Source Type: research

520PSafety of high doses of somatostatin analogs in well differentiated NENs in elderly
ConclusionsWe concluded that in this setting of patients, with an age>70 and a WD NEN in progression to standard doses of SSA, HD-SSA represents a safe and effective second line therapy with a median PFS of 20.80 months.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Contemporary surgical management of the Zollinger-Ellison syndrome in Multiple Endocrine Neoplasia type 1
Publication date: Available online 31 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Max B. Albers, Jerena Manoharan, Detlef K. BartschAbstractAbout 30% of patients with MEN1 develop a Zollinger-Ellison syndrome. Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas. Regardless of the high prevalence of early lymph...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 2, 2019 Category: Endocrinology Source Type: research

Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies.
Abstract Zollinger-Ellison syndrome (ZES) is characterized by gastric acid hypersecretion causing severe recurrent acid-related peptic disease. Excessive secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors, but surgical management to control gastrinoma itself remains controversial. Based on a thorough literature review, we design a surgical algorithm for ZES and list some significant consensus findings and recommendations: (1) For sporadic ZES, surgery should be routinely undertaken as early as possible not only for patients with a precisely localized diagnosis but also for ...
Source: World Journal of Gastroenterology : WJG - August 28, 2019 Category: Gastroenterology Authors: Shao QQ, Zhao BB, Dong LB, Cao HT, Wang WB Tags: World J Gastroenterol Source Type: research

The Gastrinoma Saga Before Zollinger and Ellison: The Strøm Case Revisited
No abstract available (Source: Annals of Surgery)
Source: Annals of Surgery - July 12, 2019 Category: Surgery Tags: BRIEF CLINICAL REPORTS Source Type: research

Large gastric folds secondary to zollinger-ellison syndrome
Endocrine Practice, Ahead of Print. (Source: Endocrine Practice)
Source: Endocrine Practice - April 23, 2019 Category: Endocrinology Authors: Raya Almazrouei Shamaila Zaman Jeannie F Todd Source Type: research

Initial Trials With Susceptibility-Based and Empiric Anti-H. pylori Therapies in Mongolia
Conclusion: In Mongolia, the prevalence of H. pylori resistance is high requiring bismuth quadruple therapy or susceptibility-based therapy to obtain acceptable cure rates. Introduction As in most developing countries, the prevalence of Helicobacter pylori infection is high in Mongolia (Nyamdavaa, 2013) with reported prevalence ranging of 80% among adults (Matsuhisa et al., 2015; Khasag et al., 2018), 64% among adolescents, and 65 and 100% among pediatric patients with gastric comorbidity (Go, 2013). Gastric cancer is a common problem in Mongolia; an age-standardized rate of 33.1 per 100,000, which is the second hi...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Classical features of Zollinger-Ellison syndrome, in images
(Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - February 5, 2019 Category: Gastroenterology Authors: Ali Alshati, Toufic Kachaamy Source Type: research

Management of Primary Lymph Nodal Gastrinoma With Liver Metastases Resulting in Zollinger-Ellison Syndrome
Primary lymph node gastrinoma has been defined as gastrin-producing tumor present in lymph nodes and predominantly found in well-defined anatomical region known as gastrinoma triangle. They are usually localized preoperatively with imaging, and their surgical resection results in long-term relief. The authors report a case of unresectable primary lymph nodal gastrinoma with liver metastases in a 14-year-old adolescent boy with proven histopathology detected on 68Ga-DOTANOC whole-body PET/CT scan followed by preoperative multiple 177Lu-DOTATATE cycles for cytoreduction. Subsequent surgical resection of residual mass resulte...
Source: Clinical Nuclear Medicine - December 23, 2018 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Proton pump inhibitors: use and misuse in the clinical setting.
Abstract INTRODUCTION: The introduction of proton pump inhibitors (PPIs) into clinical practice has greatly improved our therapeutic approach to acid-related diseases for their efficacy and safety. Areas Covered:The following evidence-based indications for PPI use are acknowledged by many scientific societies: treatment of the various forms and complications of gastroesophageal reflux disease, eradication of H. pylori infection in combination with two or more antibiotics, short- and long-term therapy of H. pylori-negative peptic ulcers, healing and prevention of NSAID/COXIB-associated gastric ulcers, co-therapy wi...
Source: Pharmacological Reviews - October 8, 2018 Category: Drugs & Pharmacology Authors: Savarino V, Marabotto E, Zentilin P, Furnari M, Bodini G, De Maria C, Pellegatta G, Coppo C, Savarino E Tags: Expert Rev Clin Pharmacol Source Type: research

Multiple Endocrine Neoplasia Type 1: A Case Report With Review of Imaging Findings.
Conclusion: This case exhibits the classic history with corresponding imaging findings of MEN1 syndrome, including pancreatic neuroendocrine tumors, parathyroid adenoma, and adrenal adenomas. High clinical suspicion for MEN1 should lead to endocrinology evaluation with appropriate laboratory workup and targeted imaging evaluation of the typical endocrine organs as described for this patient. PMID: 30258300 [PubMed] (Source: Ochsner Journal)
Source: Ochsner Journal - September 28, 2018 Category: General Medicine Tags: Ochsner J Source Type: research

Gastrinomas
This article reviews the role of surgical and medical management in patients with Zollinger-Ellison syndrome (ZES) due to a gastrin-secreting neuroendocrine tumor (gastrinoma). It concentrates on the status at present but also briefly reviews the changes over time in treatment approaches. Generally, surgical and medical therapy are complementary today; however, in some cases, such as patients with ZES and multiple endocrine neoplasia type 1, the treatment approach remains controversial. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 9, 2018 Category: Endocrinology Authors: Jeffrey A. Norton, Deshka S. Foster, Tetsuhide Ito, Robert T. Jensen Source Type: research

Old and New Gut Hormone, Gastrin and Acid Suppressive Therapy
Gastrin acts physiologically as a gut hormone to stimulate acid secretion after meal and as a cell-growth factor of oxyntic mucosa. Increase in serum gastrin level happens under various conditions including Zollinger-Ellison syndrome, antral G cell hyperplasia, autoimmune gastritis, atrophic gastritis, renal failure, vagotomy,Helicobacter pylori infection and acid suppressive therapy. As acid suppressive therapy causes hypergastrinemia, the association between acid suppressive therapy and gastric neuroendocrine cell tumor (NET) has been discussed during the past 30 years. In this review article, the definition of hypergast...
Source: Digestion - March 27, 2018 Category: Gastroenterology Source Type: research

Prospective Evaluation of Results of Reoperation in Zollinger-Ellison Syndrome
Conclusions: These results demonstrate that a significant proportion of patients with ZES will develop resectable persistent or recurrent disease after an initial operation. These patients generally have prolonged survival after reoperation and 25% can be cured with repeat surgery, suggesting all ZES patients postresection should have systematic imaging, and if tumor recurs, advise repeat operation. (Source: Annals of Surgery)
Source: Annals of Surgery - March 8, 2018 Category: Surgery Tags: Original Articles Source Type: research

Incidence and Prognosis of Primary Hepatobiliary Gastrinomas
This study investigates the incidence and prognosis of gastrinomas originating in the hepatobiliary tract in patients with Zollinger-Ellison syndrome. (Source: JAMA Surgery)
Source: JAMA Surgery - January 24, 2018 Category: Sports Medicine Source Type: research

The Zollinger-Ellison syndrome: is there a role for somatostatin analogues in the treatment of the gastrinoma?
ConclusionsThe high sstr-expression in gastrinomas make them highly responsive to SSAs and support the use of such drugs to counteract the tumour growth in patients not amenable to surgical cure. Unfortunately, limited data, mainly case reports or small series, support the use of SSAs in advanced gastrinomas, therefore, it is difficult to quantify their ability to control tumour growth and disease progression. (Source: Endocrine)
Source: Endocrine - October 10, 2017 Category: Endocrinology Source Type: research

Diagnosis and management of Zollinger-Ellison syndrome in 2017.
Authors: DE Angelis C, Cortegoso Valdivia P, Venezia L, Bruno M, Pellicano R Abstract Zollinger-Ellison Syndrome (ZES) is a clinical syndrome characterized by gastric acid hypersecretion due to the ectopic secretion of gastrin by a gastrinoma, a neuroendocrine tumor (NET) which mostly develops in the duodenum and in the pancreas. This syndrome was first described by Zollinger and Ellison in 1964; if left untreated, ZES can lead to multiple complications mainly due to gastric hypersecretion and some patients can suffer from the complications of an advanced metastatic disease. Although its clinical features are consi...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Catching the Zebra: Clinical Pearls and Pitfalls for the Successful Diagnosis of Zollinger –Ellison Syndrome
AbstractZollinger –Ellison syndrome (ZES) results from an ectopic gastrin-secreting tumor leading to peptic ulcer disease, reflux, and chronic diarrhea. While early recognition portends an excellent prognosis with>80% survival at 15  years, symptoms are often nonspecific making the diagnosis difficult to establish. Diagnosis involves a series of tests, including fasting gastrin, gastric pH, chromogranin A, and secretin stimulation. Performing these tests in the correct sequence and at the proper time is essential to avoid inac curate results. Tumor localization is equally nuanced. Although providers have clas...
Source: Digestive Diseases and Sciences - August 3, 2017 Category: Gastroenterology Source Type: research

The Effect of H2 Receptor Antagonist in Acid Inhibition and Its Clinical Efficacy.
Abstract The first histamine H2 receptor antagonists (H2RAs) were developed in the early 1970s. They played a dominant role in treating peptic ulcer disease and gastroesophageal reflux disease (GERD). H2RAs block the production of acid by H(+), K(+)-ATPase at the parietal cells and produce gastric luminal anacidity for varying periods. H2RAs are highly selective, and they do not affect H1 receptors. Moreover, they are not anticholinergic agents. Sequential development of H2RAs, proton pump inhibitors (PPIs), and discovery of Helicobacter pylori infection changed the paradigm of peptic ulcer disease with marked dec...
Source: Korean J Gastroenter... - July 23, 2017 Category: Gastroenterology Authors: Shim YK, Kim N Tags: Korean J Gastroenterol Source Type: research

Gastrointestinal: Zollinger –Ellison Syndrome: A rare cause of chronic diarrhea and abdominal pain
(Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - June 22, 2017 Category: Gastroenterology Authors: B Anderson, S Sweetser Tags: Education and Imaging Source Type: research

Zollinger & #8211;Ellison syndrome in a 12-year-old child
This report describes a 12-year-old boy who presented with refractory peptic ulcer disease which was finally diagnosed to be due to a gastrinoma and was successfully treated. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - June 8, 2017 Category: Surgery Authors: Abir Lal Nath Nandita A Saxena Bharati K Kulkarni Shyam S Borwankar Hemant N Lahoti Sanjay N Oak Source Type: research

Deprescribing versus continuation of chronic proton pump inhibitor use in adults.
CONCLUSIONS: In people with mild GERD, on-demand deprescribing may lead to an increase in GI symptoms (e.g. dyspepsia, regurgitation) and probably a reduction in pill burden. There was a decline in participant satisfaction, although heterogeneity was high. There were insufficient data to make a conclusion regarding long-term benefits and harms of PPI discontinuation, although two trials (one on-demand trial and one abrupt discontinuation trial) reported endoscopic findings in their intervention groups at study end. PMID: 28301676 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 16, 2017 Category: Journals (General) Authors: Boghossian TA, Rashid FJ, Thompson W, Welch V, Moayyedi P, Rojas-Fernandez C, Pottie K, Farrell B Tags: Cochrane Database Syst Rev Source Type: research

A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas
In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who ... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - March 7, 2017 Category: Gastroenterology Authors: Hiroyuki Matsubayashi, Noboru Kawata, Naomi Kakushima, Masaki Tanaka, Kohei Takizawa, Yoshimi Kiyozumi, Yasue Horiuchi, Keiko Sasaki, Teiichi Sugiura, Katsuhiko Uesaka and Hiroyuki Ono Source Type: research

Zollinger-Ellison syndrome: an unusual case of chronic diarrhoea in a child.
We present a rare case of a-12-year boy who initially presented with abdominal pain, diarrhoea, vomiting and progressive weight loss for over a two-year period before he was finally diagnosed as a case of ZES with the primary tumour in the pancreatic head and with multiple metastasis in both the liver and lymph nodes. PMID: 28028304 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 29, 2016 Category: Pathology Tags: Malays J Pathol Source Type: research

Assessing for multiple endocrine neoplasia type 1 in patients evaluated for Zollinger-Ellison Syndrome – clues to a safer diagnostic process
Zollinger-Ellison syndrome is a rare cause of tumoral hypergastrinemia; one out of 5 patients with this syndrome also has multiple endocrine neoplasia type 1. The diagnosis of this disease is complicated by the widespread use of proton pump inhibitors that can elevate serum gastrin levels, the cornerstone for biochemical diagnosis. Abrupt discontinuation of proton pump inhibitors could lead to adverse outcomes. Clinician awareness regarding the relationship of Zollinger Ellison syndrome and multiple endocrine neoplasia type 1, could lead to a safer diagnostic pathway. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - December 21, 2016 Category: Journals (General) Authors: Naykky Singh Ospina, Diane Donegan, Rene Rodriguez-Gutierrez, Zahraa Al-Hilli, William F. Young Tags: Brief Observation Source Type: research

Hypertrophic pyloric stenosis in a 15-year-old male
We present the case of a fifteen-year-old male with hypertrophic pyloric stenosis (HPS) thought to have originated in early infancy when chronic non-bilious emesis, early satiety and failure to thrive were evident. He developed two episodes of perforated pre-pyloric ulcer at ages 12- and 14-years. Work up for chronic Helicobacter pylori and Zollinger Ellison syndrome were negative. An upper GI study revealed a massively enlarged stomach and delayed gastric emptying. Endoscopic ultrasound revealed a thickened pylorus and a narrow pyloric canal. Electrogastrogram and antroduodenal motility studies supported a mechanical gast...
Source: Journal of Pediatric Surgery Case Reports - September 18, 2016 Category: Surgery Source Type: research

Management of gastric and duodenal neuroendocrine tumors.
Abstract Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis. Type II G-NETs (5%-6%) are associated with multiple endoc...
Source: World Journal of Gastroenterology : WJG - August 14, 2016 Category: Gastroenterology Authors: Sato Y, Hashimoto S, Mizuno K, Takeuchi M, Terai S Tags: World J Gastroenterol Source Type: research

Zollinger –Ellison Syndrome
Conclusions Endoscopists need to be aware of the classical symptoms and clinical findings associated with ZE syndrome in order to appropriately diagnose and manage affected patients. (Source: Video Journal and Encyclopedia of GI Endoscopy)
Source: Video Journal and Encyclopedia of GI Endoscopy - June 18, 2016 Category: Gastroenterology Source Type: research

Sporadic Gastric Well-Differentiated Neuroendocrine Tumors Have a Higher Ki-67 Proliferative Index
Abstract Well-differentiated neuroendocrine tumor (WDNET) of the stomach can arise in three distinct clinical settings: (1) in association with autoimmune atrophic gastritis, (2) in association with multiple neuroendocrine neoplasia type I (MEN I) or Zollinger-Ellison syndrome (ZES), or (3) sporadic. The Ki-67 proliferative index (PI) in gastric WDNETs in these three distinct clinical settings has not been evaluated in detail. Forty-five gastric WNETs underwent polypectomy (n = 4), endoscopic mucosal resection (n = 12), and surgical resection (n = 29) between 1994 and 2015 were includ...
Source: Endocrine Pathology - June 15, 2016 Category: Pathology Source Type: research

Synchronous Peripancreatic Lymph Node Gastrinoma and Gastric Neuroendocrine Tumor Type 2.
Authors: Lee HW, Chung JW, Kim YJ, Kwon KA, Kim EJ, Kim KK, Lee WK, Sym SJ Abstract A 34-year-old man was referred to our hospital with gastric polypoid lesions and biopsy-confirmed neuroendocrine tumor (NET). Computed tomography (CT) revealed a 3×3.5×8-cm retroperitoneal mass behind the pancreas, with multiple hepatic metastases. His serum gastrin level was elevated to 1,396 pg/mL. We performed a wedge resection of the stomach, a right hemi-hepatectomy, and a retroperitoneal mass excision. After careful review of the clinical, radiological, histopathological, and immunohistochemical findings, peripancr...
Source: Clinical Endoscopy - May 23, 2016 Category: Gastroenterology Tags: Clin Endosc Source Type: research

Stereoselective Pharmacodynamics and Pharmacokinetics of Proton Pump Inhibitors.
Abstract Proton pump inhibitors (PPIs) are a group of gastric acid suppressing drugs, that are strong and long-lasting inhibitors of the proton pump (referred to as acid pump antagonists). They work by irreversibly blocking the H+/K+ ATPase. PPIs are used to treat peptic ulcer disease, gastroesophageal reflux disease, nonsteroidal anti-inflammatory drug-induced gastrointestinal lesions, and Zollinger-Ellison syndrome. The structure of PPIs are similar, they all have a similar core with a sulphur atom chiral center combined with different substituent groups. In relation to the sulphur atom chiral center, the pharma...
Source: Current Drug Metabolism - March 22, 2016 Category: Drugs & Pharmacology Authors: Yang ZC, Yu F, Wang YQ, Wei JF Tags: Curr Drug Metab Source Type: research

Comment prendre en charge les tumeurs carcinoïdes gastriques ?
Résumé Les tumeurs neuroendocrines bien différenciées de l’estomac sont principalement fundiques. Les deux situations fréquentes sont: 1/ les tumeurs multiples associées à une gastrite chronique fundique auto-immune (maladie de Biermer) (type 1) où l’hypergastrinémie réactionnelle est responsable d’une hyperplasie des cellules endocrines fundiques puis du développement de ces tumeurs ; et 2/ les tumeurs uniques dites sporadiques (type 3) qui apparaissent en dehors de tout contexte particulier (pas d’hypergastrin&ea...
Source: Acta Endoscopica - February 10, 2016 Category: Gastroenterology Source Type: research

Weight Gain in Zollinger-Ellison Syndrome After Acid Suppression
Objectives: Zollinger-Ellison syndrome (ZES) is characterized by hypergastrinemia and gastric acid hypersecretion resulting in peptic ulcer disease, diarrhea, and weight loss. Acid secretion can be controlled with medication, and biochemical cure is possible with surgery. Data on how these interventions affect patients’ weight are lacking. We aimed to determine how medical and surgical acid control affects weight over time. Methods: We performed a retrospective cohort study on 60 ZES patients. Acid control was achieved with appropriate-dose proton pump inhibitor (PPI) therapy. Surgery was performed for curative inte...
Source: Pancreas - January 12, 2016 Category: Gastroenterology Tags: Original Articles Source Type: research

Pancreatic Tumor in a Patient With Parathyroid and Pituitary Disease
This distal pancreatic mass occurred in a patient with a history of primary hyperparathyroidism (diagnosed in childhood), Zollinger Ellison syndrome, and a pituitary prolactinoma. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - January 1, 2016 Category: Internal Medicine Authors: Sounak Gupta, Lori A. Erickson Tags: Path to patient image quiz Source Type: research

Syndromic versus non-syndromic sporadic gastrin-producing neuroendocrine tumors of the duodenum: comparison of pathological features and biological behavior
Abstract Sporadic gastrin-producing neuroendocrine tumors of the duodenum present either with the Zollinger-Ellison syndrome (ZES) or with unspecific symptoms. While syndromic gastrin-producing neuroendocrine tumors often show metastases at the time of diagnosis, those without a syndrome do not. The aim of the study was to search for clinicopathological features that may distinguish the two categories of gastrin-producing duodenal tumors. In a retrospective study, we analyzed the clinical and pathological data in a series of 41 patients with syndromic (i.e., gastrinomas) or non-syndromic duodenal gastrin-producing...
Source: Virchows Archiv - December 9, 2015 Category: Pathology Source Type: research

Diagnostic and Treatment Approaches for Refractory Peptic Ulcers.
Authors: Kim HU Abstract Refractory peptic ulcers are defined as ulcers that do not heal completely after 8 to 12 weeks of standard anti-secretory drug treatment. The most common causes of refractory ulcers are persistent Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Simultaneous use of two or more H. pylori diagnostic methods are recommended for increased sensitivity. Serologic tests may be useful for patients currently taking proton pump inhibitors (PPIs) or for suspected false negative results, as they are not affected by PPI use. NSAID use should be discontinued when po...
Source: Clinical Endoscopy - November 18, 2015 Category: Gastroenterology Tags: Clin Endosc Source Type: research

A short history of neuroendocrine tumours and their peptide hormones
Publication date: Available online 23 October 2015 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Wouter W. de Herder, Jens F. Rehfeld, Mark Kidd, Irvin M. Modlin The discovery of neuroendocrine tumours of the gastrointestinal tract and pancreas started in 1870, when Rudolf Heidenhain discovered the neuroendocrine cells, which can lead to the development of these tumours. Siegfried Oberndorfer was the first to introduce the term carcinoid in 1907. The pancreatic islet cells were first described in 1869 by Paul Langerhans. In 1924, Seale Harris was the first to describe ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - October 23, 2015 Category: Endocrinology Source Type: research

Gastric Hypersecretory States: Investigation and Management
Opinion statement Hypersecretory conditions affecting the stomach account for significant morbidity and mortality manifested in some cases with peptic ulcer, gastrointestinal hemorrhage, and/or gastroesophageal reflux disease (GERD). The diagnosis of gastric acid hypersecretory states can be challenging and relies on the use of quantitative assays to measure gastric acid secretion and serum gastrin. The most common etiology for hypergastrinemia is the use of potent gastric acid inhibitors such as the proton pump inhibitors. The differential diagnosis of this condition is of critical importance, and will dictate ma...
Source: Current Treatment Options in Gastroenterology - September 5, 2015 Category: Gastroenterology Source Type: research

Biochemical Testing in Patients with Neuroendocrine Tumors.
Authors: Granberg D Abstract Neuroendocrine tumors are usually slow-growing tumors. Many of these are capable of secreting peptide hormones or biogenic amines that may lead to endocrine syndromes. Nonfunctioning tumors can either secrete no hormones at all, or secrete hormones not giving rise to endocrine symptoms, such as chromogranin A, chromogranin B or pancreatic polypeptide. Chromogranin A is produced by the majority of endocrine tumors, both functioning and nonfunctioning, and is the best available marker for diagnosis, follow-up and treatment monitoring of patients with differentiated neuroendocrine tumors. ...
Source: Frontiers of Hormone Research - August 27, 2015 Category: Endocrinology Tags: Front Horm Res Source Type: research

Somatostatin analogs for gastric carcinoids: For many, but not all.
Abstract Gastric carcinoids (GCs) are classified as: type I, related to hypergastrinemia due to chronic atrophic gastritis (CAG), type II, associated with Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1, and type III, which is normogastrinemic. The management of type-I gastric carcinoids (GC1s) is still debated, because of their relatively benign course. According to the European Neuroendocrine Tumor Society guidelines endoscopic resection is indicated whenever possible; however, it is not often feasible because of the presence of a multifocal disease, large lesions, submucosal invasion or, r...
Source: World Journal of Gastroenterology : WJG - June 14, 2015 Category: Gastroenterology Authors: Massironi S, Zilli A, Conte D Tags: World J Gastroenterol Source Type: research

Surgery for gastrinoma: Short and long-term results.
ina A Abstract INTRODUCTION: Zollinger-Ellison syndrome (Z-E) is characterized by gastrin-secreting tumors, responsible for causing refractory and recurrent peptic ulcers in the gastrointestinal tract. The optimal approach and the extension of tumor resection remains the subject of debate. PATIENTS AND METHODS: During the period February 2005 and February 2014, 6 patients with Z-E underwent surgery, 4 men and 2 women with a median age 46.8 years (22-61). Two patients were affected with multiple endocrine neoplasia type-1 (MEN-1). Fasting gastrin levels greater than 200pg/ml (NV:
Source: Cirugia eEspanola - March 3, 2015 Category: Surgery Authors: Fernández-Cruz L, Pelegrina A Tags: Cir Esp Source Type: research