Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Parasitic infections related to anti-type 2 immunity monoclonal antibodies: a disproportionality analysis in the food and drug administration ’s adverse event reporting system (FAERS)
Conclusion: Parasitic infections were disproportionately reported for mAbs targeting IgE, T2 cytokines, or T2 cytokine receptors. While the number of adverse event reports on parasitic infections in the database was relatively low, resulting safety signals were disproportionate and warrant further investigation. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Source Type: research
Omalizumab improves sinonasal outcomes in patients with chronic rhinosinusitis with nasal polyps regardless of allergic status
CONCLUSION: In patients with CRSwNP, omalizumab improved sinonasal outcomes independent of allergic status, which suggests that a wide range of patients with different endotypes and phenotypes of CRSwNP may benefit from omalizumab treatment.PMID:37951571 | DOI:10.1016/j.anai.2023.11.001 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Philippe Gevaert Joaquim Mullol Rebecca Saenz Jinnie Ko John W Steinke Lauren A Millette Eli O Meltzer Source Type: research
Omalizumab Therapy of Bullous Pemphigoid
Br J Dermatol. 2023 Nov 6:ljad432. doi: 10.1093/bjd/ljad432. Online ahead of print.NO ABSTRACTPMID:37939788 | DOI:10.1093/bjd/ljad432 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2023 Category: Dermatology Authors: Janet A Fairley Kelly A N Messingham Source Type: research
Omalizumab Therapy of Bullous Pemphigoid
Br J Dermatol. 2023 Nov 6:ljad432. doi: 10.1093/bjd/ljad432. Online ahead of print.NO ABSTRACTPMID:37939788 | DOI:10.1093/bjd/ljad432 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2023 Category: Dermatology Authors: Janet A Fairley Kelly A N Messingham Source Type: research
Omalizumab improves sinonasal outcomes in patients with chronic rhinosinusitis with nasal polyps regardless of allergic status
Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have atopic comorbidities, including elevated immunoglobulin E (IgE) levels and comorbid asthma. Omalizumab, an IgE monoclonal antibody, is an effective treatment for CRSwNP, but the impact of allergy or asthma status on response to omalizumab in patients with CRSwNP has not been well studied. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 8, 2023 Category: Allergy & Immunology Authors: Philippe Gevaert, Joaquim Mullol, Rebecca Saenz, Jinnie Ko, John W. Steinke, Lauren A. Millette, Eli O. Meltzer Tags: Original Article Source Type: research
IgE directly affects eosinophil migration in CRSwNP through CCR3 and predicts the efficacy of omalizumab
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2023 Category: Allergy & Immunology Authors: Jiaqi Yu, Bing Yan, Shen Shen, Yang Wang, Ying Li, Feifei Cao, Wei Xiong, Yingshi Piao, Chen Hu, Ying Sun, Luo Zhang, Chengshuo Wang Source Type: research
IgE directly affects eosinophil migration in chronic rhinosinusitis with nasal polyps through CCR3 and predicts the efficacy of omalizumab
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease resulting from persistent inflammation of the sinonasal mucosa that affects approximately 2% of the general adult population worldwide.1-3 CRSwNP significantly reduces health-related quality of life, increases the risk of depression and anxiety,4,5 and presents a large health and economic burden.6 Eosinophilic CRSwNP is one of the most relapsed CRSwNP, which has been shown to have greater clinical severity and is often associated with asthma comorbidity, loss of smell, extensive sinus disease, higher recurrence rate, and poorer prognosis, thus cau...
Source: Journal of Allergy and Clinical Immunology - November 1, 2023 Category: Allergy & Immunology Authors: Jiaqi Yu, Bing Yan, Shen Shen, Yang Wang, Ying Li, Feifei Cao, Wei Xiong, Yingshi Piao, Chen Hu, Ying Sun, Luo Zhang, Chengshuo Wang Source Type: research
