Combined analytical assays for the characterization of drugs binding to human IgE: Applicability to omalizumab-bearing biosimilar candidates assessment
Biomed Pharmacother. 2023 Nov 14;169:115848. doi: 10.1016/j.biopha.2023.115848. Online ahead of print.ABSTRACTAnalytical and functional comparison is key for substantiating the level of convergence (essential sameness) or divergence between versions or variants of a given biological medicine. Accordingly, an overlapping biological activity between products meant to be equal probably reflects a highly similar structure and anticipates a comparable pharmacodynamic behavior. We developed an orthogonal approach to compare the human IgE binding features of different lots and versions of Xolair® (omalizumab), an anti-human IgE ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 17, 2023 Category: Drugs & Pharmacology Authors: Adri án Urbano Judith Plaza C ésar Picado Fernando de Mora Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
Food oral immunotherapy: Any distinguishing factors predicting the need of anti-IgE?
In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment. It was also aimed to share the clinical findings regarding the long-term use of OMZ and the withdrawal process. Forty-one patients were started OIT and 93% could be desensitized. Two groups were similar in means of demographic characteristics, and clinical and laboratory findings. The patients who needed OMZ during OIT had also lower reaction doses during oral challenge (p = 0.037). Higher AR rate in this group declined after starting OMZ (p < 0.001). The in...
Source: Allergologia et Immunopathologia - November 16, 2023 Category: Allergy & Immunology Authors: Sanem Eren Akarcan Handan Duman Şenol Figen G ülen Esen Demir Source Type: research
