X-Linked Agammaglobulinemia (XLA) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A Case of Rare Splice Site Bruton's Tyrosine Kinase Mutation with Atypical X-linked Agammaglobulinemia
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by reduced mature peripheral B cells and hypogammaglobulinemia caused by mutations in the gene (Btk) encoding for the B-cell receptor (BCR) signal transduction molecule, Bruton's tyrosine kinase, BTK.1 The gene is located at Xq21.3-Xq22 on the X chromosome and various types of mutations have been documented. The largest database of mutations, originally founded for XLA, is called the BTKbase. Of these, splice-site mutations make up 16% of cases. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 9, 2022 Category: Allergy & Immunology Authors: Sanghwa E Park, Brittanie I Neaves, Karla Adams Tags: Letters Source Type: research

X-linked Agammaglobulinemia: Infection Frequency and Infection-Related Mortality in the USIDNET Registry
O ’Toole D, Groth D, Wright H. J Clin Immunol. 2022;42(4):827–836 (Source: PEDIATRICS)
Source: PEDIATRICS - December 1, 2022 Category: Pediatrics Source Type: research

Cytomegalovirus Pneumonia in a Patient with X-Linked Agammaglobulinemia: A Case Report
Medicina (Kaunas). 2022 Oct 15;58(10):1457. doi: 10.3390/medicina58101457.ABSTRACTX-linked agammaglobulinemia (XLA) is a hereditary immune disorder that predisposes patients to frequent and severe bacterial infections caused by encapsulated bacteria (such as Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenzae). Otitis media, sinusitis, and pneumonia are common complications of XLA that require prompt diagnosis and treatment. Cytomegaloviruses (CMV) cause widespread and severe infections in immunocompromised individuals, affecting the respiratory tract, and consequently, leading to pneumonia, which i...
Source: Medicina (Kaunas) - October 27, 2022 Category: Universities & Medical Training Authors: Yao-Xian Wong Shyh-Dar Shyur Source Type: research

Comparison of pulmonary lesions using lung ultrasound and high-resolution computed tomography in adult patients with primary humoral immunodeficiencies
This study aimed to evaluate lung lesions using simultaneous LUS and HRCT in a group of patients with PADs. Twenty-nine adult patients (13 women and 16 men) diagnosed with PADs according to the ESID criteria (23 Common variable immunodeficiency, 2 X-linked agammaglobulinemia, 2 IgG subclass deficiencies, and 2 Unspecified hypogammaglobulinemia) were included in the study. The mean age was 39.0 ± 11.9 years. The mean time elapsed between the first symptoms of PADs and the examination was 15.4 ± 10.1 years. Lung ultrasonography and high-resolution computed tomography were performed simultaneously according to a defined pro...
Source: Frontiers in Immunology - October 25, 2022 Category: Allergy & Immunology Source Type: research

Immunogenicity and Safety of the Spikevax ® (Moderna) mRNA SARS-CoV-2 Vaccine in Patients with Primary Humoral Immunodeficiency
Conclusion: Spikevax ® seems to be safe with satisfactory immunogenicity in patients with primary humoral immunodeficiency.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - October 6, 2022 Category: Allergy & Immunology Source Type: research