X-Linked Agammaglobulinemia (XLA) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Immunologic Control of Disseminated Aichi Virus Infection in X-Linked Agammaglobulinemia by Transplantation of TcR αβ-Depleted Haploidentical Hematopoietic Cells
(Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - July 5, 2022 Category: Allergy & Immunology Source Type: research

Successful use of dupilumab to treat eczema in a child with X-linked agammaglobulinemia
Ann Allergy Asthma Immunol. 2022 Jun 27:S1081-1206(22)00539-7. doi: 10.1016/j.anai.2022.06.020. Online ahead of print.NO ABSTRACTPMID:35772636 | DOI:10.1016/j.anai.2022.06.020 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - June 30, 2022 Category: Allergy & Immunology Authors: Sanmeet Atwal Peck Y Ong Source Type: research

Successful use of dupilumab to treat eczema in a child with X-linked agammaglobulinemia
We described here a child with X-linked agammaglobulinemia (XLA) who developed severe generalized eczema that was unresponsive to mid-potency topical corticosteroid but eventually responded to dupilumab. The patient is an 11 year-old male who initially presented to our clinic at 11 months of age after he was discharged from an outside pediatric intensive care unit due to respiratory distress needing intubation and assisted ventilation. He was treated with intravenous antibiotics and eventually recovered. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - June 27, 2022 Category: Allergy & Immunology Authors: Sanmeet Atwal, Peck Y Ong Source Type: research

T Cell Abnormalities in X-Linked Agammaglobulinaemia: an Updated Review
AbstractX-linked agammaglobulinaemia (XLA) is a primary immunodeficiency (PID) resulting from a defect in the B cell development. It has conventionally been thought that T cells play a major role in the development and function of the B cell compartment. However, it has also been shown that B cells and T cells undergo bidirectional interactions and B cells also influence the structure and function of the T cell compartment. Patients with XLA offer a unique opportunity to understand the effect of absent B cells on the T cell compartment. In this review, we provide an update on abnormalities in the T cell compartment in pati...
Source: Clinical Reviews in Allergy and Immunology - June 16, 2022 Category: Allergy & Immunology Source Type: research

Neutralizing SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Give Patients with X-Linked Agammaglobulinemia Limited Passive Immunity to the Omicron Variant
In conclusion, 2 years into the pandemic the amounts of antibodies to SARS-CoV-2 vary considerably among commercial Ig batches obtained from three co mmercial producers. Importantly, in batches with high concentrations of antibodies directed against the original virus strain, protective passive immunity to the Omicron variant appears to be insufficient. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - May 11, 2022 Category: Allergy & Immunology Source Type: research

Successful dupilumab therapy for atopic dermatitis in a patient with X-linked agammaglobulinaemia
(Source: European Journal of Dermatology)
Source: European Journal of Dermatology - May 1, 2022 Category: Dermatology Source Type: research

Campylobacter jejuni Pericarditis: A Case Report
We report a case of pericarditis in a patient with X-linked agammaglobulinemia presenting with chronic diarrhea and chest pain who evolved to cardiac tamponade, requiring a pericardial window and a long course of broad-spectrum antibiotics. To the best of our knowledge, this is the third case of pericarditis caused by Campylobacter jejuni reported in the literature, the second in a patient with X-linked agammaglobulinemia. Despite its rarity, this case serves as a reminder of Campylobacter as a potential cause of cardiac inflammation for clinicians treating pericarditis/myocarditis, especially in patients with a history of...
Source: Acta Medica Portuguesa - April 28, 2022 Category: General Medicine Authors: Joao Neves-Maia Catarina Gomes Ant ónio Marinho Rute Alves Source Type: research