X-Linked Agammaglobulinemia (XLA) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Relapsing < em > Helicobacter cinaedi < /em > Cellulitis without Bacteremia in a Patient with X-linked Agammaglobulinemia after 1 Year of Antibiotic Prophylaxis
Skinmed. 2022 Dec 20;20(6):457-459. eCollection 2022.ABSTRACTA 23-year-old man with Bruton's X-linked agammaglobulinemia (XLA), who required intravenous immunoglobulin G (IgG) every 3 weeks, presented with an erythematous scaly eruption adjacent to the chest port for antibiotic therapy (Figures 1A,B). His past medical history included Helicobacter cinaedi cellulitis in 2015 that was treated with intravenous vancomycin and ertapenem with no improvement after several months. The therapy was switched to ertapenem and amikacin, which was also unsuccessful after 1 year. Subsequently, on switching to oral doxycycline for 6 month...
Source: Skinmed - December 20, 2022 Category: Dermatology Authors: Volha Lenskaya Megan O'Connor Ellen H de Moll Garrett Desman Source Type: research

A Case of Rare Splice Site Bruton's Tyrosine Kinase Mutation with Atypical X-linked Agammaglobulinemia
Ann Allergy Asthma Immunol. 2022 Dec 9:S1081-1206(22)01989-5. doi: 10.1016/j.anai.2022.12.004. Online ahead of print.NO ABSTRACTPMID:36509410 | DOI:10.1016/j.anai.2022.12.004 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 12, 2022 Category: Allergy & Immunology Authors: Sanghwa E Park Brittanie I Neaves Karla Adams Source Type: research

A case of rare splice-site Bruton's tyrosine kinase mutation with atypical X-linked agammaglobulinemia
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by reduced mature peripheral B cells and hypogammaglobulinemia caused by mutations in the gene (Btk) encoding for the B-cell receptor (BCR) signal transduction molecule, Bruton's tyrosine kinase, BTK.1 The gene is located at Xq21.3-Xq22 on the X chromosome and various types of mutations have been documented. The largest database of mutations, originally founded for XLA, is called the BTKbase. Of these, splice-site mutations make up 16% of cases. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 9, 2022 Category: Allergy & Immunology Authors: Sanghwa E. Park, Brittanie I. Neaves, Karla Adams Tags: Letters Source Type: research