Regular Physical Activity at Any Time in Life Improves Late Life Brain Health
Researchers here look at epidemiological data on physical activity and brain function in old age. While the presence of any period of life in which physical activity was a regular occurrence correlates with improved late life brain health, the best option is to remain active throughout life. When it comes to established human data, the effects of exercise and calorie restriction remain the bar to beat for any attempt to improve healthspan and longevity across a broad population of varied individuals. We might hope that at least the use of senolytics to clear senescent cells//en.wikipedia.org/wiki/Cellular_senescence">senes...
Source: Fight Aging! - March 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 6th 2023
In conclusion, our study reveals that aging enhances atherosclerosis via increased inflammation of visceral fat. Our study suggests that future therapies targeting the visceral fat may reduce atherosclerosis diseaseburden in the expanding older population.
Is the Gut a Significant Source of Amyloid-β in Alzheimer's Disease?
https://www.fightaging.org/archives/2023/02/is-the-gut-a-significant-source-of-amyloid-%ce%b2-in-alzheimers-disease/
The early stages of Alzheimer's disease are characterized by rising levels of amyloid-β in the brain and the formation of misfolded amyloid aggregates. It is present...
Source: Fight Aging! - February 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Does Mitochondrial Dysfunction Meaningfully Contribute to the Development of Atherosclerosis?
Mitochondria are the power plants of the cell, producing the chemical energy store molecule ATP, but are also integrated into a wide range of fundamental cellular processes. Mitochondrial function declines with age, likely an important contribution to age-related declines in energy-hungry tissues such as the brain and muscles. It is also known that mitochondrial dysfunction can provoke chronic inflammation via the mislocation of mitochondrial DNA into parts of the cell where it will act as a damage-associated molecular pattern. This upregulation of inflammatory signaling is a reasonable proposal for the way in which mitoch...
Source: Fight Aging! - January 30, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes.
Communication Between Blood and Brain in Aging and Rejuvenation
https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/
As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inte...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senotherapeutics Will Reduce the Side-Effects of Cancer Radiotherapy
Treatment with radiation to kill cancerous cells results in an increased burden of senescent cells, both in and around the tumor. This is a fair trade-off; a senescent cancerous cell may be harmful in and of itself, but it is a good deal less harmful in the long run than an active cancer cell. Unfortunately senescent cells produce pro-growth, pro-inflammatory signaling that is disruptive of tissue function, raises the risk of suffering a range of age-related conditions, and increases the risk of both reoccurrence of the treated cancer and the development of later unrelated cancers.
Thus given the work taking place o...
Source: Fight Aging! - January 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Chicken with Dried Mushrooms & Tomatoes
When it comes time to figure out what to make for dinner, I love the internet as much as anyone. I usually head straight to the NY Times Cooking section, or to Epicurious, Saveur or Food 52 for ideas and inspiration. But one weekend this past year, with our Philly travel plans cancelled by an upcoming storm (there is nothing worse than the Jersey turnpike in a thunderstorm with tornado and flood warnings), I had the unexpected luxury of free time on a Saturday morning. Sitting with a cup of coffee, I opened Biba’s Taste of Italy, a cookbook whose spine I had yet to crack in the year since it had been gifted to me by ...
Source: The Blog That Ate Manhattan - January 19, 2023 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Meat & Poultry Borgotaro braised Chicken Dinner party Dried mushrooms Emilia Romagna italian Make-ahead PGI Porcini recipe Stove top Tomatoes Source Type: blogs
Is AI the Beginning or End of Learning? | TAPP 131
In Episode 131, Kevin Patton discusses the use ofChatGPT and otherchatbots andartificial intelligence (AI) in teaching and learning. We learn what ' s going on, what to be concerned about, and what to look forward to. And how tokeep breathing.0:00:00 | Introduction0:00:53 | What ' s a Chatbot and Why Should I Care?0:08:44 | Sponsored by AAA0:09:51 | Kevin Asks ChatGPT Some Questions0:21:25 | Sponsored by HAPI0:22:01 | Is ChatGPT Amazing? Is It Accurate?0:37:23 | Sponsored by HAPS0:38:11 | Arms Race or Tool Box?0:46:55 | Calculators, Typewriters, and Grammarly0:58:36 | Cool Tools and Alternative Assessments1:06:20...
Source: The A and P Professor - January 19, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
The joy of having many data points
Researchers and clinicians are drawn to studies with many participants. Especially randomised controlled trials, where two groups are randomly divided and one gets “the real thing” while the other does not. The joy comes from knowing that results from these kinds of studies suggest that, all things being equal, the differences between the groups is “real” and not just by chance.
When we come to analyse the graphs from these kinds of studies, what we hope to see are two nice bell-shaped curves, with distinct peaks (the arithmetic mean) and long tails either side – and a clear separation betw...
Source: HealthSkills Weblog - December 11, 2022 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Assessment Occupational therapy Physiotherapy Professional topics Psychology Research Science in practice Uncategorized Chronic pain Clinical reasoning Health pain management Therapeutic approaches Source Type: blogs
More about Mastodon and more
While Mastodon (I’m @sciencebase there and here’s my Mastodon FAQ) has become perhaps one of the most talked about alternatives to Twitter in recent weeks, there is plenty more to investigate in the alternative, federated social media world. This infographic from the JoinFediverse Wiki shows some of the many branches on the Fediverse tree. I’ll leave Sciencebase readers to do their own searching of the terms on the tree, but they’re all linked from here. Some of the terms and systems have been around a long time.
Click the graphic to see the latest full-size version
Part of the ethos of the fedivers...
Source: David Bradley Sciencebase - Songs, Snaps, Science - November 23, 2022 Category: Science Authors: David Bradley Tags: Social Media Source Type: blogs
20 years of open science or how we haven't radically changed the way we do science online
Around 20 years ago I was a starting PhD student and it was an exciting time for the internet. It was the time of blogs, wikis and a large increase in public participation with more user generated content in what is commonly known as the start of Web 2.0. These were the times of web based online communities such as the now defunct Kuro5hin or the great survivor slashdot.org. I started this blog 19 years ago and I was also " hanging out " in an online community called Nodalpoint. Nodalpoint no longer exists but it was a discussion forum/wiki for bioinformatics with some of these discussions st...
Source: Evolution of Cellular Networks - November 16, 2022 Category: Cytology Tags: open science Source Type: blogs
What Duplicate Patient Notes Reveal About Health Care and Its Records
Bloat in patient notes has been alarming doctors for some time. The American Medical Informatics Association began a project to reduce patient documentation to 25% of its current volume by 2025. This task won’t be solved by any single organizer or sector; the AMIA calls on providers and health systems, Health IT vendors, and policy and advocacy groups to join the effort.
A recent study in a JAMA publication, “Prevalence and Sources of Duplicate Information in the Electronic Medical Record,” helps drive discussion of bloat forward by focusing on one manifestation: the duplication of text from one patient n...
Source: EMR and HIPAA - November 11, 2022 Category: Information Technology Authors: Andy Oram Tags: AI/Machine Learning Ambulatory Clinical EMR-EHR Health IT Company Healthcare IT AdvancedMD Amazon Comprehend Medical AMIA billing CipherHealth Cloudticity Cumberland Heights Foundation Donna Pritchard Doug McGill EHR Document Source Type: blogs
And you thought Mastadons were extinct …
by KIM BELLARD
Until last week, for me, “mastodon” only meant the giant animal that went extinct several thousand years ago (I was, it appears, unaware of the heavy metal band Mastodon). Now, as the result of Elon Musk’s purchase of Twitter, many Twitter users are being forced to take a look at alternatives, such as the social networking site Mastodon.
It’s possible that we are about the witness the Myspace-ization of Twitter, brought down by competition, bad management, and bad product decisions. In my usual “there must be a pony in here somewhere” fashion, there may be some lessons in the Twitter saga ...
Source: The Health Care Blog - November 8, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Elon Musk Kim Bellard Mastadon Twitter Source Type: blogs
Understand risk better by using "micromort" unit
A micromort (from micro- and mortality) is a unit of risk defined as a one-in-a-million chance of death.Micromorts can be used to measure the riskiness of various day-to-day activities.Activities that increase the death risk by roughly one micromort, and their associated cause of death:Traveling 250 miles by car (collision) Travelling 1,000 miles (1,600 km) by jet (collision) Travelling 6,000 miles (9,656 km) by train (collision) Increase in death risk for other activities on a per event basis:Giving birth (vaginal) – 120 micromortsGiving birth (caesarean) – 170 micromortsAstraZeneca vaccination against COVID-19 ...
Source: Clinical Cases and Images - Blog - October 27, 2022 Category: Universities & Medical Training Source Type: blogs
Censoring Truthful Speech About Judges Violates the First Amendment
Thomas A. BerryCan the government censor you for wishing a judge happy birthday? It may seem absurd, but a bill that would allow exactly that was recentlyadded to theNational Defense Authorization Act. If passed into law, every American would risk facing mandatory takedown orders for posting basic facts about federal judges online, including their birthdates, the colleges attended by their children, and the jobs of their spouses. The bill stifles access to relevant information about public officials, arbitrarily limits its restrictions to the internet but not other media, and allows speech to be suppressed even i...
Source: Cato-at-liberty - October 17, 2022 Category: American Health Authors: Thomas A. Berry Source Type: blogs
After A Couple Of Weeks It Is Clear That The “Optus Hack” Was A Symptom Of A Larger Problem!
As time passes we are starting to see more considered comments on the issue.Here for example:Optus data breach reveals ad hoc and immature response systemThe near 10 million Optus customers at the centre of the identity credential scandal were essentially left to fend for themselves.Tom BurtonGovernment editorOct 2, 2022 – 2.39pmRevelations that nearly 10 million Australians have had key identity credentials potentially breached finally provided the shock needed to modernise the country ’s antiquated data management, security and privacy systems.For years, under intense lobbying from financial, payment, telco, media an...
Source: Australian Health Information Technology - October 9, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
