Acquired Digital Fibrokeratoma: A Report of Five Cases and Review of the Literature
Clin Cosmet Investig Dermatol. 2024 Jan 30;17:247-252. doi: 10.2147/CCID.S447798. eCollection 2024.ABSTRACTAcquired digital fibrokeratoma (ADF) is rare in clinical practice and is easily misdiagnosed. Herein, 5 cases of patients (3 males and 2 females) with ADF are reported. The mean age at onset was 42.6 years, and the mean disease duration was 3 years. Four patients had ADF on the hands, and 1 patient had ADF on the foot. The clinical manifestations were all solitary, skin-colored papules, with a firm texture and smooth surface, protruding from the skin surface. In 3 patients, ADF manifested as columnar protrusions, and ...
Source: Clinical, Cosmetic and Investigational Dermatology - February 5, 2024 Category: Dermatology Authors: Xing Wang Dong Zhang Qingxia Lin Changying Niu Huiping Fan Mogen Zhang Xiangfeng Yuan Weiyuan Ma Source Type: research
A ProTide of AZT Shows Activity Against Human Papillomaviruses
ChemMedChem. 2024 Jan 19:e202300661. doi: 10.1002/cmdc.202300661. Online ahead of print.ABSTRACTInfection by human papillomaviruses (HPV) can cause warts and tumors. So far, no small molecule antiviral has been approved for the treatment of infections with this DNA virus, although preclinical studies show activity for nucleosidic compounds, such as 9-(2-phosphonylmethoxy)ethylguanine (PMEG) or cidofovir. This prompted us to test new prodrug versions of the nucleoside analog 3'-azido-2',3'-dideoxythymidine (AZT), known to be active against reverse transcriptases and approved for the treatment of HIV. Here we report the synt...
Source: ChemMedChem - January 19, 2024 Category: Chemistry Authors: Tim Gniech Adrian Humboldt Kathy A Keith Scott H James Clemens Richert Source Type: research
The quality of life of frequently vs. infrequently screened HPV vaccinated women
ConclusionThere was no significant difference in the QoL of HPV vaccinated women between the two CC screening arms. Women were mostly satisfied with the screening experience despite the screening frequency. This information is important for the future screening program planning as we need to reach the best possible balance with screening benefits and harms.Trial registration numberNCT02149030, date of registration 29/5/2014. (Source: Quality of Life Research)
Source: Quality of Life Research - January 18, 2024 Category: Health Management Source Type: research
Periodontal disease in patients with WHIM syndrome
CONCLUSIONS: Overall, WHIM syndrome patients presented with an increased severity of periodontitis despite past and ongoing neutrophil mobilization treatments. GOF mutations in CXCR4 may be a risk factor for periodontitis in humans.PMID:38185798 | DOI:10.1111/jcpe.13940 (Source: Journal of Clinical Periodontology)
Source: Journal of Clinical Periodontology - January 7, 2024 Category: Dentistry Authors: Laurie Brenchley David H McDermott Pamela J Gardner Lakmali M Silva Ji-Liang Gao Elena Cho Daniel Velez Niki M Moutsopoulos Philip M Murphy David Fraser Source Type: research
Periodontal disease in patients with WHIM syndrome
CONCLUSIONS: Overall, WHIM syndrome patients presented with an increased severity of periodontitis despite past and ongoing neutrophil mobilization treatments. GOF mutations in CXCR4 may be a risk factor for periodontitis in humans.PMID:38185798 | DOI:10.1111/jcpe.13940 (Source: Journal of Clinical Periodontology)
Source: Journal of Clinical Periodontology - January 7, 2024 Category: Dentistry Authors: Laurie Brenchley David H McDermott Pamela J Gardner Lakmali M Silva Ji-Liang Gao Elena Cho Daniel Velez Niki M Moutsopoulos Philip M Murphy David Fraser Source Type: research
Characteristics of cervical cancer caused by the human papillomavirus 18 and its genetic variations in Vietnamese women
CONCLUSION: Patients with a single HPV18 infection have a higher risk of cervical cancer than those infected with HPV18 and other high-risk strains simultaneously. HPV18 single-infection, on the other hand, had considerably higher incidences of L/HSIL, SCC, AC, and CIS than HPV18 co-infection. The HPV18 strain that was found in Vietnam belonged to lineage A (A1 and A5), which contains several oncogene mutations.PMID:38176603 | DOI:10.1016/j.meegid.2023.105546 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 4, 2024 Category: Genetics & Stem Cells Authors: Than Manh Hung Hoang Xuan Son Le Van Nguyen Bang Le Van Duyet Source Type: research
Characteristics of cervical cancer caused by the human papillomavirus 18 and its genetic variations in Vietnamese women
CONCLUSION: Patients with a single HPV18 infection have a higher risk of cervical cancer than those infected with HPV18 and other high-risk strains simultaneously. HPV18 single-infection, on the other hand, had considerably higher incidences of L/HSIL, SCC, AC, and CIS than HPV18 co-infection. The HPV18 strain that was found in Vietnam belonged to lineage A (A1 and A5), which contains several oncogene mutations.PMID:38176603 | DOI:10.1016/j.meegid.2023.105546 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 4, 2024 Category: Genetics & Stem Cells Authors: Than Manh Hung Hoang Xuan Son Le Van Nguyen Bang Le Van Duyet Source Type: research
Basal spot junctions of Drosophila epithelial tissues respond to morphogenetic forces and regulate Hippo signaling
Dev Cell. 2023 Dec 19:S1534-5807(23)00622-6. doi: 10.1016/j.devcel.2023.11.024. Online ahead of print.ABSTRACTOrgan size is controlled by numerous factors including mechanical forces, which are mediated in part by the Hippo pathway. In growing Drosophila epithelial tissues, cytoskeletal tension influences Hippo signaling by modulating the localization of key pathway proteins to different apical domains. Here, we discovered a Hippo signaling hub at basal spot junctions, which form at the basal-most point of the lateral membranes and resemble adherens junctions in protein composition. Basal spot junctions recruit the central...
Source: Developmental Cell - December 22, 2023 Category: Cytology Authors: Benjamin Kroeger Samuel A Manning Yoshana Fonseka Viola Oorschot Simon A Crawford Georg Ramm Kieran F Harvey Source Type: research
Basal spot junctions of Drosophila epithelial tissues respond to morphogenetic forces and regulate Hippo signaling
Dev Cell. 2023 Dec 19:S1534-5807(23)00622-6. doi: 10.1016/j.devcel.2023.11.024. Online ahead of print.ABSTRACTOrgan size is controlled by numerous factors including mechanical forces, which are mediated in part by the Hippo pathway. In growing Drosophila epithelial tissues, cytoskeletal tension influences Hippo signaling by modulating the localization of key pathway proteins to different apical domains. Here, we discovered a Hippo signaling hub at basal spot junctions, which form at the basal-most point of the lateral membranes and resemble adherens junctions in protein composition. Basal spot junctions recruit the central...
Source: Developmental Cell - December 22, 2023 Category: Cytology Authors: Benjamin Kroeger Samuel A Manning Yoshana Fonseka Viola Oorschot Simon A Crawford Georg Ramm Kieran F Harvey Source Type: research
Different skin wart types, different human papillomavirus types? A narrative review
Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):165-171.ABSTRACTSkin warts are ubiquitous, self-limiting, benign neoplasms caused by human papillomaviruses (HPV). Several studies have investigated the prevalence and diversity of HPV types in the three main types of skin warts: common, plantar, and flat warts. Using different methodological approaches and diverse populations, several HPV types were detected in skin warts, but often the etiological link remained unconfirmed. This review addresses recently improved multiple strategies for investigating the presence of HPVs in skin warts, covering proper sampling tech...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Lucijan Skubic Vesna Breznik Mario Poljak Source Type: research
