Decision tree analysis to predict the risk of intracranial haemorrhage after mild traumatic brain injury in patients taking DOACs - Turcato G, Zaboli A, Pfeifer N, Maccagnani A, Tenci A, Giudiceandrea A, Zannoni M, Ricci G, Bonora A, Brigo F.
BACKGROUND: Although the preliminary evidence seems to confirm a lower incidence of post-traumatic bleeding in patients treated with direct oral anticoagulants (DOACs) compared to those on vitamin K antagonists (VKAs), the recommended management of mild tr... (Source: SafetyLit)
Source: SafetyLit - September 6, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
' Less Is More' for Edoxaban in Post-TAVI Anticoagulation: ENVISAGE-TAVI AF'Less Is More' for Edoxaban in Post-TAVI Anticoagulation: ENVISAGE-TAVI AF
Although edoxaban was associated with similar net adverse cardiac events as vitamin K antagonists, it was linked to high rates of major bleeding in this phase 3b study.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - August 28, 2021 Category: Cardiology Tags: Cardiology News Source Type: news
Vitamin K Inversely Linked to Risk for Atherosclerotic CVD
MONDAY, Aug. 16, 2021 -- Diets high in vitamin K1 and K2 are inversely associated with the risk for atherosclerotic cardiovascular disease (ASCVD), according to a study published online Aug. 7 in the Journal of the American Heart Association.
Jamie... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 16, 2021 Category: Pharmaceuticals Source Type: news
How to live longer: A tea made from a fruit rich in vitamin K keeps the heart healthy
HOW TO live longer can be achieved by simply adding more fruits and vegetables rich in vitamins and minerals. One such fruit made into a tea is said to help lower cholesterol and keep the heart healthy, and it is more healthy than kale. (Source: Daily Express - Health)
Source: Daily Express - Health - August 6, 2021 Category: Consumer Health News Source Type: news
Outcomes of Upper GI Bleeding: DOACs vs. Vitamin K Antagonists Outcomes of Upper GI Bleeding: DOACs vs. Vitamin K Antagonists
This study investigated whether direct oral anticoagulants alter outcomes of upper GI bleeding as compared to vitamin K antagonists.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 22, 2021 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
Non-vitamin K Oral Anticoagulants and Risk of Fractures Non-vitamin K Oral Anticoagulants and Risk of Fractures
Is the risk of fracture associated with the use of NOACs lower than that seen with vitamin K antagonists in patients with atrial fibrillation?Europace (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 8, 2021 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
NOACs in Adults With Congenital Heart Disease NOACs in Adults With Congenital Heart Disease
A new study suggests that non-vitamin K oral anticoagulants might not be the best choice in adults with congenital heart disease.European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 27, 2021 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
Efficacy, Safety of NOACs Following Cardiac Valve Replacement Efficacy, Safety of NOACs Following Cardiac Valve Replacement
How does the efficacy and safety of nonvitamin K oral anticoagulants compare to vitamin K antagonists following bioprosthetic cardiac valve replacement?Southern Medical Journal (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - January 20, 2021 Category: Surgery Tags: Family Medicine/Primary Care Journal Article Source Type: news
Efficacy, Safety of NOACs Following Cardiac Valve Replacement Efficacy, Safety of NOACs Following Cardiac Valve Replacement
How does the efficacy and safety of nonvitamin K oral anticoagulants compare to vitamin K antagonists following bioprosthetic cardiac valve replacement?Southern Medical Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 20, 2021 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation
Vitamin K antagonists are widely used anticoagulants that target vitamin K epoxide reductases (VKOR), a family of integral membrane enzymes. To elucidate their catalytic cycle and inhibitory mechanism, we report 11 x-ray crystal structures of human VKOR and pufferfish VKOR-like, with substrates and antagonists in different redox states. Substrates entering the active site in a partially oxidized state form cysteine adducts that induce an open-to-closed conformational change, triggering reduction. Binding and catalysis are facilitated by hydrogen-bonding interactions in a hydrophobic pocket. The antagonists bind specificall...
Source: ScienceNOW - December 31, 2020 Category: Science Authors: Liu, S., Li, S., Shen, G., Sukumar, N., Krezel, A. M., Li, W. Tags: Biochemistry, Online Only r-articles Source Type: news
New XARELTO ® (rivaroxaban) Peripheral Artery Disease (PAD) Data from EXPLORER Clinical Research Program to be Unveiled at American Heart Association (AHA) Scientific Sessions 2020
RARITAN, N.J., November 9, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that 10 data presentations will be shared at the virtual American Heart Association (AHA) Scientific Sessions 2020 from November 13-17. Most notably, four new sub-analyses of XARELTO® (rivaroxaban) from the landmark VOYAGER PAD trial, part of the EXPLORER global cardiovascular research program, will be presented, including two live, featured science oral presentations. “We're pleased VOYAGER PAD was selected to be front and center once again at a major medical congress, as there's an urgent need for data in ...
Source: Johnson and Johnson - November 9, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news
Warfarin Use Linked to Knee and Hip Replacement in OA Patients Warfarin Use Linked to Knee and Hip Replacement in OA Patients
Patients who take vitamin K antagonist warfarin to prevent thromboembolic events are significantly more likely to require knee or hip replacement surgery than those who take direct oral anticoagulants.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 9, 2020 Category: Cardiology Tags: Rheumatology News Source Type: news
Importance of segmental hair analysis in a suspected case of attempted homicide by flocoumafen and difenacoum - Carelli C, Fais P, Freni F, Moretti M, Vignali C, Morini L.
The 4-hydroxycoumarin derivatives are the most used rodenticides and act as classical anticoagulants, interfering with the production of clotting factors in liver by antagonizing the action of vitamin K reductase, thereby inhibiting recycling of vitamin K1... (Source: SafetyLit)
Source: SafetyLit - September 2, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
New vitamin K-based drug shows promise against medication-resistant epilepsy
(Medical University of South Carolina) Medical University of South Carolina researchers have designed a new vitamin K-based compound that shows excellent seizure-control properties, even in preclinical models of medication-resistant seizures. Over 1 million people in the US suffer from medication-resistant epilepsy, contending with poor quality of life due to unpredictable seizures. This vitamin K analog, with its unique structure and low toxicity, could one day be a boon for patients whose seizures are not controlled by standard medications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 6, 2020 Category: International Medicine & Public Health Source Type: news
Anticoagulants' Safety and Effectiveness in General Practice Anticoagulants' Safety and Effectiveness in General Practice
This study compared safety and effectiveness between patients treated with vitamin K antagonists and patients treated with direct oral anticoagulants in a general practice setting.Annals of Family Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 16, 2020 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
