TWiV 851: Questions are tricky
The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) Omicron infection in mice and hamsters (Res Square) Letters read on TWiV 851 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Engineering the James Webb Space Telescope Amy – T cells might be our bodies’ best shot agai...
Source: This Week in Virology - MP3 Edition - January 9, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 850: COVID-19 clinical update #96 with Dr. Daniel Griffin
In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant proportions (CDC) Omicron in South Africa (JAMA) Transmission of SARS-CoV-2 (Ann Int Med) Diagnostics for COVID-19 (Lancet) Comparison of rapid antigen tests (J Clin Med) Rapid antigen tests to reduce isolation (medRxiv) Frequency of viral confections (MMWR) Iso...
Source: This Week in Virology - MP3 Edition - January 8, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 849: Arc of the epitope
TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID vaccines: TWiV 708, 715, 718, 844 Non-CoV papers: TWiV 763, 784, 819, 822, 740, 848 Immune correlates of protection: TWiV 791, 799, 835, 832, 841, 789 Fitness: TWiV 705, 836, 768, 757 Guests off beaten track: 723, 726, 732, 838, 773, 745 Lab leak nonsense: TWiV 762, 774 One...
Source: This Week in Virology - MP3 Edition - January 7, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 847: On Dasher, on Dancer, on Corona and Lassa
For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Codon-deoptimized Lassa fever vaccine (mBio) Attenuation of dengue virus by codon deoptimization (TWiV 351) Codon deoptimization of poliovirus and RS virus (TWiV 740) Codon deoptimization of DNA viruses (TWiV 362 lett...
Source: This Week in Virology - MP3 Edition - January 2, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 848: COVID-19 clinical update #95 with Dr. Daniel Griffin
In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron outbreaks in Nebraska and Denmark, Baylor's COVID vaccine, and COVID-OUT for ivermectin. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Isolation and quarantine guidance (CDC) EUA for Molnupiravir (FDA) Children and COVID state data (AAP) Vaccine safety in 5-11 year olds (MMWR) Omicron and antigen tests (FDA) Omicron in Nebraska (MMWR) Omicron in Danish households (medRxiv) ...
Source: This Week in Virology - MP3 Edition - January 1, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 846: Beta was stirring, and now in a mouse
TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Impact of enteric virome on rotavirus vaccine (Cell Host Micr) Beta variant infects wild type mice (Sig Transd Targ Ther) Timestamps by Jolene. Thanks! Weekly Picks Brianne – XKCD on Immune Responses and Immunity Kathy – UVA Rotunda ...
Source: This Week in Virology - MP3 Edition - December 26, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 845: COVID-19 clinical update #94 with Dr. Daniel Griffin
In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines, Molnupiravir in non-hospitalized patients, and convalescent serum in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA EUA for Paxlovid (pdf) Children and COVID-19 (pdf) Evaluation of test to stay in school, IL (MMWR) Evaluation of test to stay in school, LA (MMWR) Update on mRNA vaccine in under 5 yo (Pfizer) ...
Source: This Week in Virology - MP3 Edition - December 25, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 844: COVID, children, and boosters with Paul Offit
Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guest: Paul Offit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Paul Offit on TWiV 720 Are COVID-19 vaccine boosters needed? (virology blog) Letters read on TWiV 844 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Vaccine Scientists: Time’s 2021 Heroes of the Year Kathy – Snake dietary diversity Vincent...
Source: This Week in Virology - MP3 Edition - December 19, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 844: Paul Offit on children, COVID, and boosters
Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guest: Paul Offit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Paul Offit on TWiV 720 Are COVID-19 vaccine boosters needed? (virology blog) Letters read on TWiV 844 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Vaccine Scientists: Time’s 2021 Heroes of the Year Kathy – Snake dietary diversity Vincent...
Source: This Week in Virology - MP3 Edition - December 19, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 843: COVID-19 clinical update #93 with Dr. Daniel Griffin
In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant updates (CDC) List of diagnostic kits (Global Fund, pd...
Source: This Week in Virology - MP3 Edition - December 18, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 842: The clot thickens
TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Third vaccine dose improves Omicron neutralization (medRxiv) ChAdOX1 interacts with PF4 (Sci Adv) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Vaccine Scientists: Time’s ...
Source: This Week in Virology - MP3 Edition - December 16, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 841: Unmasking immunity
TWiV provides an update on immunity to Omicron, results of a randomized controlled trial of face masks, and a study of correlates of protection against respiratory syncytial virus infection in the upper and lower respiratory tract of nonhuman primates. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron escape from serum antibodies (pdf) Pfizer/BioNTech update on Omicron (Pfizer) Randomized trial of masking for COVID-19 (Science) Upper and lower respiratory tract correlates of prot...
Source: This Week in Virology - MP3 Edition - December 12, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 840: COVID-19 clinical update #92 with Dr. Daniel Griffin
In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, FDA EUA for pre-exposure prophylaxis, outcomes after treatment, and investigation of subcutaneous or intramuscular administration; effect of adding immunomodulatory agents to usual care on thromboembolic events, and long COVID following infection in previously vaccinated individuals. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this ep...
Source: This Week in Virology - MP3 Edition - December 11, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 839: The long and the short of it: get vaccinated
TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus in the US (NY Times) Omicron variant (NY Times) West Nile virus transmission by organ transplantation (Emerg Inf Dis) Stronger antibody response after 16 week mRNA dose (Cell Host Micr) Higher antib...
Source: This Week in Virology - MP3 Edition - December 9, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 838: The magic virus bus
The New York City Virus Hunters join TWiV to reveal how local students engage in safe virus surveillance and conduct science research right in their neighborhoods, followed by an update on variant of concern Omicron. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Teresa Bautista, Isabel Francisco, Jesus Gonzales, Joel Gonzalez, Florian Krammer, and Christine Marizzi, Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Biobus Wild Bird Fund FluLab B1.1.529 (COVID-19-lineages) Report on Omicron spike changes (virological) Omicro...
Source: This Week in Virology - MP3 Edition - December 5, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
